Article detail · 2022
An Alternative Autophagy-Related Mechanism of Chloroquine Drug Resistance in the Malaria Parasite
Antimicrobial Agents and Chemotherapy
YÖKSİS
OpenAlex
Open access · green
SJR Q1
JCR Q1
Citations 4
Percentile 70.2%
FWCI 0.63
- Year
- 2022
- ISSN
3634-2168- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
English (OpenAlex)
We generated highly chloroquine (CQ)-resistant (ResCQ) Plasmodium yoelii parasites by stepwise exposure to increasing concentrations of CQ and CQ-sensitive parasites (SenCQ) by parallel mock treatments. No mutations in genes that are associated with drug resistance were detected in ResCQ clones. Autophagy-related genes were highly upregulated in SenCQ compared to ResCQ parasites during CQ treatment. This indicates that CQ resistance can be developed in the malaria parasite by the inhibition of autophagy as an alternative drug resistance mechanism.
Topics
- Mosquito-borne diseases and control
- Malaria Research and Control
- Autophagy in Disease and Therapy
Primary topic Mosquito-borne diseases and control