Article detail · 2016
Cerebral small vessel disease Capillary pathways to stroke and cognitive decline
Journal
Journal of Cerebral Blood Flow & MetabolismISSN 0271-678X
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2016
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Journal of Cerebral Blood Flow & Metabolism
- Catalog match (ISSN) Journal of Cerebral Blood Flow and Metabolism
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Cerebral small vessel disease (SVD) gives rise to one in five strokes worldwide and constitutes a major source of cognitive decline in the elderly. SVD is known to occur in relation to hypertension, diabetes, smoking, radiation therapy and in a range of inherited and genetic disorders, autoimmune disorders, connective tissue disorders, and infections. Until recently, changes in capillary patency and blood viscosity have received little attention in the aetiopathogenesis of SVD and the high risk of subsequent stroke and cognitive decline. Capillary flow patterns were, however, recently shown to limit the extraction efficacy of oxygen in tissue and capillary dysfunction therefore proposed as a source of stroke-like symptoms and neurodegeneration, even in the absence of physical flow-limiting vascular pathology. In this review, we examine whether capillary flow disturbances may be a shared feature of conditions that represent risk factors for SVD. We then discuss aspects of capillary dysfunction that could be prevented or alleviated and therefore might be of general benefit to patients at risk of SVD, stroke or cognitive decline.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
281 citations
OpenAlex cited_by_count (cache / database)
7 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Small Vessels Are a Big Problem in Neurodegeneration and Neuroprotection 2019
- Pericytes in the brain and heart: functional roles and response to ischaemia and reperfusion 2024
- Pericytes: A Novel Target to Improve Success of Recanalization Therapies 2019
- Pericytes in Ischemic Stroke 2019
- The effect of carotid artery stenting on capillary transit time heterogeneity in patients with carotid artery stenosis 2018
- Role of Pericytes in Neurovascular Unit and Stroke 2016
- Where and how do leukocytes stall in retinal microcirculation: A spatiotemporal analysis with a focus on junctions and pericytes. 2025