Article detail · 2021
Synthesis and anticancer activities of some new coumarin derivatives including the triazole ring and their in silico molecular docking studies
- Year
- 2021
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Archiv der Pharmazie
- Catalog match (ISSN) Archiv der Pharmazie
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
The synthesis, docking study, and investigation of the anticancer activities of some coumarin derivatives containing the triazole ring are reported in this study. The newly synthesized compounds were screened for their in vitro anticancer activity against the cell lines CRL5807 (human bronchioalveolar carcinoma), CRL5826 (human squamous cell carcinoma), MDA-MB231 (human breast cancer cells), HTB177 (human lung cancer), PC-3 (human prostate adenocarcinoma), PANC-1 (human pancreatic cancer cells), used as cancer cells, and CCD34Lu (normal human lung fibroblasts), used as a healthy cell line. Cytotoxicity effects of the samples were determined by the MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) assay. In silico studies were also performed to explore the binding interactions of the molecules.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
15 citations
OpenAlex cited_by_count (cache / database)
16 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Development of novel 1,2,4-triazole containing compounds with anticancer and potent anti-CB1 activity. 2024
- Developing Effective Antimicrobial Agents: Synthesis and Molecular Docking Study of Ciprofloxacin-Benzimidazole Hybrids 2024
- Developing Effective Antimicrobial Agents: Synthesis and Molecular Docking Study of Ciprofloxacin‐Benzimidazole Hybrids 2024
- Developing Effective Antimicrobial Agents: Synthesis and Molecular Docking Study of Ciprofloxacin‐Benzimidazole Hybrids 2024
- Developing Effective Antimicrobial Agents: Synthesis and Molecular Docking Study of Ciprofloxacin‐Benzimidazole Hybrids 2024
- Novel Coumarin Derivatives Containing a Triazole Moiety: A Study on Synthesis, Cytotoxicity, Membrane Dysfunction, Apoptosis, Cell Cycle, and Antiangiogenic Effects 2022
- Novel Coumarin Derivatives Containing A Triazole Moiety: A Study On Synthesis, Cytotoxicity, Membrane Dysfunction, Apoptosis, Cell Cycle, And Antiangiogenic Studies 2022
- Novel Coumarin Derivatives Containing a Triazole Moiety: A Study on Synthesis, Cytotoxicity, Membrane Dysfunction, Apoptosis, Cell Cycle, and Antiangiogenic Effects 2022
- Design, Synthesis, and Structure–Activity Relationship of Some New Ciprofloxacin Hybrids as Antibacterial Agents 2025
- Design, Synthesis, and Structure–Activity Relationship of Some New Ciprofloxacin Hybrids as Antibacterial Agents 2025