Article detail · 2013
In vitro synergistic activity of colistin with tigecycline or lactam antibiotic lactamase inhibitor combinations against carbapenem resistant Acinetobacter baumannii
Journal
J Int Med Res.ISSN 0300-0605
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2013
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue J Int Med Res.
- Catalog match (ISSN) Journal of International Medical Research
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
OBJECTIVE: Nosocomial infection caused by carbapenem-resistant Acinetobacter baumannii is a worldwide problem and treatment options remain controversial. This study investigated the in vitro effect of various antibiotic combinations against carbapenem-resistant A. baumannii strains. METHODS: Antibiotic susceptibility of A. baumannii strains was analysed. In vitro synergistic efficacy of colistin combined with tigecycline, cefoperazone/sulbactam or piperacillin/tazobactam was tested against carbapenem-resistant A. baumannii strains. Synergy studies were performed using an eplisometer test-strip method. RESULTS: Of the 50 carbapenem-resistant A. baumannii strains tested, 96% were susceptible to colistin and 64% were susceptible to tigecycline. Colistin-tigecycline, colistin-cefoperazone/sulbactam and colistin-piperacillin/tazobactam combinations were found to have synergistic effects against six (12%), two (4%), and one (2%), respectively, of the strains tested. CONCLUSIONS: Colistin combined with tigecycline, cefoperazone/sulbactam or piperacillin/tazobactam revealed synergistic effects in some carbapenem-resistant A. baumannii strains. These results, together with the shortage of treatment options and the risk of developing resistance to colistin, suggest that clinicians should use colistin combined with other antibiotics or β-lactamase inhibitors when treating carbapenem-resistant A. baumannii infection.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
36 citations
OpenAlex cited_by_count (cache / database)
9 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- In vitro Activity of Colistin in Combination with Tigecycline against Carbapenem-Resistant Acinetobacter baumannii Strains Isolated from Patients with Ventilator-Associated Pneumonia 2015
- In vitro Activity of Colistin in Combination with Tigecycline against Carbapenem Resistant Acinetobacter baumannii Strains Isolated from Patients with Ventilator Associated Pneumonia 2015
- In vitro Activity of Colistin in Combination with Tigecycline against Carbapenem-Resistant Acinetobacter baumannii Strains Isolated from Patients with Ventilator-Associated Pneumonia 2015
- In vitro Activity of Colistin in Combination with Tigecycline against Carbapenem Resistant Acinetobacter baumannii StrainsIsolated from Patients with Ventilator Associated Pneumonia 2015
- In vitro Activity of Colistin in Combination with Tigecycline against Carbapenem Resistant Acinetobacter baumannii Strains Isolated from Patients with Ventilator Associated Pneumonia 2015
- Antibiotic Resistance Profiles and Genotypes of Acinetobacter baumannii Isolates and In Vitro Interactions of Various Antibiotics in Combination with Tigecycline and Colistin 2017
- Genetıc diversity of Acinetobacter baumannii strains isolated in different hospitals 2023
- GENETIC DIVERSITY OF ACINETOBACTER BAUMANNII STRAINS ISOLATED IN DIFFERENT HOSPITALS 2023
- GENETIC DIVERSITY OF ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM DIFFERENT HOSPITALS 2023