Article detail · 2022
Effect of low and high dose of favipiravir on ovarian and reproductive function in female rats: Biochemical and histopathological evaluation
- Year
- 2022
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue General physiology and biophysics
- Catalog match (ISSN) General Physiology and Biophysics
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Favipiravir is a drug which shows antiviral activity by inhibiting RNA-dependent RNA polymerase. Favipiravir causes severe adverse effects at high doses. The aim of this study was to investigate the effects of low and high dose favipiravir on ovarian and reproductive function in female rats. The rats were divided into three groups: HG group (healthy rats), FAV-100 group (rats administered 100 mg/kg favipiravir), and FAV-400 group (rats administered 400 mg/kg favipiravir) with 12 rats in each group. Favipiravir was administered orally twice daily for 1 week. Six rats from each group were euthanized and their ovaries were removed. Oxidative and antioxidant parameters were measured in ovarian tissues and examined histopathologically. The remaining animals were kept to breed. Animals receiving favipiravir had increased oxidant content, decreased antioxidant activity, decreased histopathological damage, infertility, and gestational delay. Favipiravir treatment should be used with caution, especially in women of reproductive age.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
8 citations
OpenAlex cited_by_count (cache / database)
31 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Pulmonary toxicity associated with high-dose favipiravir and treatment options: biochemical and histopathological evaluation. 2024
- Pulmonary toxicity associated with high-dose favipiravir and treatment options: biochemical and histopathological evaluation. 2024
- Pulmonary toxicity associated with high-dose favipiravir and treatment options: biochemical and histopathological evaluation. 2024
- Pulmonary toxicity associated with high-dose favipiravir and treatment options: biochemical and histopathological evaluation. 2024
- Pulmonary toxicity associated with high-dose favipiravir and treatment options: biochemical and histopathological evaluation. 2024
- Pulmonary toxicity associated with high-dose favipiravir and treatment options: biochemical and histopathological evaluation. 2024
- Pulmonary toxicity associated with high-dose favipiravir and treatment options: biochemical and histopathological evaluation. 2024
- Pulmonary toxicity associated with high-dose favipiravir and treatment options: biochemical and histopathological evaluation. 2024
- Pulmonary toxicity associated with high-dose favipiravir and treatment options: biochemical and histopathological evaluation. 2024
- Association of Tramadol-Induced Ovarian Damage and Reproductive Dysfunction with Adenosine Triphosphate and the Protective Role of Exogenous ATP Treatment 2025