Article detail · 2021
Synthesis and characterization of bile acid‐based polymeric micelle as a drug carrier for doxorubicin
- Year
- 2021
- DOI
- 10.1002/pat.5478
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Polymers for Advanced Technologies
- Catalog match (ISSN) Polymers for Advanced Technologies
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Abstract In the present study, a polymeric micelle based on amphiphilic block copolymer, namely poly(methacrylated methyl lithocholate)‐block‐poly(oligoethylene glycol methacrylate) (PMML‐b‐POEGMA) bearing bile acid moiety is prepared via sequential photo‐initiated free radical polymerizations, and its drug carrying capacity is investigated using doxorubicin hydrochloride (DOX) as a model drug. For this purpose, two‐step procedure is applied in the presence of phenylbis (2,4,6‐trimethylbenzoyl)phosphine oxide (BAPO) as bifunctional photo initiator. Based on spectroscopic and chromatographic analyses, the desired amphiphilic block copolymer (PMML‐b‐POEGMA) is successfully synthesized by wavelength‐selective free radical photopolymerization under mild conditions. Finally, the DOX drug is loaded into the PMML‐b‐POEGMA micelles and then drug release behavior is investigated at two different pH (5.5 and 7.4) values. It is concluded from the results that PMML‐b‐POEGMA micelles may be used as an efficient nanocarrier to deliver conventional anti‐cancer drugs for combination chemotherapy.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
15 citations
OpenAlex cited_by_count (cache / database)
7 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Synthesis of Sorafenib−Ruthenium Complexes, Investigation of Biological Activities and Applications in Drug Delivery Systems as an Anticancer Agent 2024
- Synthesis of Sorafenib−Ruthenium Complexes, Investigation of Biological Activities and Applications in Drug Delivery Systems as an Anticancer Agent 2024
- Synthesis of Sorafenib−Ruthenium Complexes, Investigation of Biological Activities and Applications in Drug Delivery Systems as an Anticancer Agent 2024
- Synthesis of Sorafenib−Ruthenium Complexes, Investigation of Biological Activities and Applications in Drug Delivery Systems as an Anticancer Agent 2024
- Glycopolymeric Photoactive Micelles for Glucose Transporter-Targeted Synergistic Combination Therapy 2024
- Glycopolymeric Photoactive Micelles for Glucose Transporter-Targeted Synergistic Combination Therapy 2024
- Biopolymers containing bile acid derivatives: Recent advances, material comparisons, and application prospects 2025