Article detail · 2021
Curcumin nanoparticles supported gelatin-collagen scaffold: Preparation, characterization, and in vitro study
Journal
Elsevier BVISSN 2214-7500
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2021
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Elsevier BV
- Catalog match (ISSN) Toxicology Reports
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
It is possible to reveal the potential of water-insoluble drugs by increasing their solubility in water with some nanotechnology techniques. Nanosuspension technology can solve this problem by increasing the water solubility and as well as bioavailability of these drugs. The present work is pointed at the evaluation of nanosuspension of curcumin, a poorly water-soluble drug. The Curcumin nanoparticules (CNs) were prepared with ultrasonnication method using dichloromethane as solvent and water as antisolvent and characterized via spectroscopic methods (UV–vis and FT-IR) and Scanning Electron Microscopy (SEM). Curcumin nanoparticules Biofilms (CNs-BF) supported gelatin-collagen scaffold were prepared. Curcumin nanoparticles were obtained by nanosuspension technique. And then, to overcome the limited effects of curcumin such as solubility and bioavailability, nanoparticle films were prepared by incorporating it into the structure of biocompatible collagen-gelatin scaffolds. Curcumin is limited by some factors that limit its clinical applicability, such as low oral bioavailability, poor water solubility and rapid degradation. However, they can be applied clinically when they are included in the structure of biocompatible gelatin-collagen scaffolds.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
14 citations
OpenAlex cited_by_count (cache / database)
8 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Curcumin nanoparticles impregnated collagen/demineralized bone matrix/olive leaves extract biocomposites as a potential bone implant: Preparation, characterization, and biocompatibility 2023
- Curcumin nanoparticles impregnated collagen/demineralized bone matrix/olive leaves extract biocomposites as a potential bone implant: Preparation, characterization, and biocompatibility 2023
- Efficacy of glycoprotein-based nanocurcumin/silk fibroin electrospun scaffolds: Perspective for bone apatite formation 2022
- Fabrication of cylindrical bone graft substitute supported by reduced graphene-oxide and nanocurcumin to promotes the bone tissue development 2022
- Novel water-soluble gelatin-based platinum nanoparticles for targeted cancer therapy with enhanced cytotoxicity 2025
- Novel water-soluble gelatin-based platinum nanoparticles for targeted cancer therapy with enhanced cytotoxicity 2025
- Novel water-soluble gelatin-based platinum nanoparticles for targeted cancer therapy with enhanced cytotoxicity 2025
- Novel water-soluble gelatin-based platinum nanoparticles for targeted cancer therapy with enhanced cytotoxicity 2025