Article detail · 2015
Long term outcome of patients with spinal myxopapillary ependymoma treatment results from the MD Anderson Cancer Center and institutions from the Rare Cancer Network
- Year
- 2015
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Neuro-Oncology
- Catalog match (ISSN) Neuro-Oncology
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
BACKGROUND: Spinal myxopapillary ependymomas (MPEs) are slowly growing ependymal gliomas with preferential manifestation in young adults. The aim of this study was to assess the outcome of patients with MPE treated with surgery, radiotherapy (RT), and/or chemotherapy. METHODS: The medical records of 183 MPE patients (male: 59%) treated at the MD Anderson Cancer Center and 11 institutions from the Rare Cancer Network were retrospectively reviewed. Mean patient' age at diagnosis was 35.5 ± 15.8 years. Ninety-seven (53.0%) patients underwent surgery without RT, and 86 (47.0%) were treated with surgery and/or RT. Median RT dose was 50.4 Gy. Median follow-up was 83.9 months. RESULTS: Fifteen (8.2%) patients died, 7 of unrelated cause. The estimated 10-year overall survival was 92.4% (95% CI: 87.7-97.1). Treatment failure was observed in 58 (31.7%) patients. Local failure, distant spinal relapse, and brain failure were observed in 49 (26.8%), 17 (9.3%), and 11 (6.0%) patients, respectively. The estimated 10-year progression-free survival was 61.2% (95% CI: 52.8-69.6). Age (<36 vs ≥36 y), treatment modality (surgery alone vs surgery and RT), and extent of surgery were prognostic factors for local control and progression-free survival on univariate and multivariate analysis. CONCLUSIONS: In this series, treatment failure of MPE occurred in approximately one third of patients. The observed recurrence pattern of primary spinal MPE was mainly local, but a substantial number of patients failed nonlocally. Younger patients and those not treated initially with adjuvant RT or not undergoing gross total resection were significantly more likely to present with tumor recurrence/progression.
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Citations
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130 citations
OpenAlex cited_by_count (cache / database)
12 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype 2015
- Clinicopathologic features of anaplastic myxopapillary ependymomas 2018
- Evaluation of pediatric spinal ependymomas: A 25-year retrospective observational study 2024
- An Extremely Rare Case of Back and Hip Pain due to the Metastasis of Late Recurrent Myxopapillary Ependymoma to the Inguinal Lymph Node 2018
- The Present and Future Opportunities of the Rare Cancer Network: An International Consortium for Advancement of Oncologic Care 2015
- The Present and Future Opportunities of the Rare Cancer Network: An International Consortium for Advancement of Oncologic Care 2015
- PRENATAL DÖNEMDEN İTİBAREN SİSTEMİK FLUOR VERİLEN SIÇANLARIN BÖBREK DOKULARINDA GÖRÜLEN APOPTOZİSİN İNCELENMESİ 2020
- Analyses of Copy Number Variations in Myxopapillary Ependymomas of Cauda Equina 2020
- Analyses of Copy Number Variations in Myxopapillary Ependymomas of Cauda Equina 2020
- Analyses of Copy Number Variations in Myxopapillary Ependymomas of Cauda Equina. 2020