Article detail · 2021
Platelet to lymphocyte ratio in differentiation of benign and malignant thyroid nodules
Journal
Experimental Biomedical ResearchISSN 2618-6454
- Year
- 2021
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Experimental Biomedical Research
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Aim: Differentiation of thyroid nodules, either as benign or malignant, is a real diagnostic challenge.Inflammation has an important role in development of the malignancy.Therefore, inflammatory markers are associated with malignant thyroid nodules.Platelet /lymphocyte ratio (PLR) is also one of the novel inflammatory indices derived from hemogram tests.We hypothesized whether PLR was associated with malignant thyroid nodules.For this purpose, we compared PLR levels of the patients with benign thyroid nodules to the PLR of the subjects with malignant nodules.Methods: The subjects who visited outpatient internal medicine clinics of our institution with a diagnosis of thyroid nodule were enrolled to the present retrospective study.According to the examination of the fine needle aspiration cytology (FNAC) specimen of the nodules, patients grouped into benign or malignant nodule groups.PLR of groups were compared.Results: Median PLR values of the benign and malignant thyroid nodule groups were 106 (48-432) % and 119 (48-365) %, respectively (p=0.001).PLR value higher than 106% has 69% sensitivity and 51% specificity in detecting malignant nodules (AUC: 0.59, p=0.001, 95% CI: 0.54-0.65).PLR was positively correlated with TSH level (r=0.10,p=0.34).Conclusion: We suggest that elevated PLR could be an additional tool to differentiate malignant thyroid nodules from benign ones in supportive of sonography, scintigraphy and cytology.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
49 citations
OpenAlex cited_by_count (cache / database)
22 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
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- A Novel Inflammatory Marker for the Diagnosis of Hashimoto’s Thyroiditis: Platelet-Count-to-Lymphocyte-Count Ratio 2023
- A Novel Inflammatory Marker for the Diagnosis of Hashimoto’s Thyroiditis: Platelet-Count-to-Lymphocyte-Count Ratio 2023
- Ferritin/lymphocyte percentage ratio to predict the severity and mortality of COVID-19 2023
- Incidental Papillary Microcarcinoma and Papillary Thyroid Carcinoma in Multinodular Goiter 2023
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- Incidental Papillary Microcarcinoma and Papillary Thyroid Carcinoma in Multinodular Goiter 2023
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- Evaluation of descriptive performances of platelet indices, neutrophil/lymphocyte ratio, and platelet/lymphocyte ratio in aortic dissections 2023
- Prognostic value of complete blood count parameters in COVID-19 patients 2022