Article detail · 2023 · article
Development of a Chemogenetic Approach to Manipulate Intracellular pH
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- YÖKSİSYÖKSİS article record
- YÖKSİS venueJournal of the American Chemical Society
- Catalog match (ISSN)Journal of the American Chemical Society
- OpenAlexOpenAlex enrichment (abstract, citations, topics)
Abstract
Chemogenetic Operation of iNTRacellular prOton Levels (pH-Control) is a novel substrate-based enzymatic method that enables precise spatiotemporal control of ultralocal acidification in cultured cell lines and primary neurons. The genetically encoded biosensor SypHer3s showed that pH-Control effectively acidifies cytosolic, mitochondrial, and nuclear pH exclusively in the presence of β-chloro-d-alanine in living cells in a concentration-dependent manner. The pH-Control approach is promising for investigating the ultralocal pH imbalance associated with many diseases.
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Citations
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9citationsOpenAlex · cited_by_count (cache / database)
5 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
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- 2024 Genetically Encoded Biosensors Unveil Neuronal Injury Dynamics via Multichromatic ATP and Calcium ImagingCitations 5 · OpenAlex
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