Article detail · 2014
The Effect of Agomelatine on Nociceptive System
Journal
Bulletin of Clinical PsychopharmacologyISSN 1017-7833
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2014
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Bulletin of Clinical Psychopharmacology
- Catalog match (ISSN) Klinik Psikofarmakoloji Bulteni
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
English (OpenAlex)
Objective: The aim of the study was to study the effects of agomelatine, an antidepressant, on the nociceptive system.Methods: Twenty four male Swiss albino mice (four months old and 28.8±1.18 g average weight) were randomly divided into three groups, which were equal in numbers; Group A and B were the experimental groups and group C was the control group. Group A was given 12.5 mg/kg of agomelatine, Group B was given 25 mg/kg agomelatine and Group C was given physiological saline via intraperitoneal injection. To evaluate the nociceptive effects, by using the hot plate method (50°C), pain threshold values of the control and agomelatine groups were recorded as the 30th and 60th minute findings.Results: According to the pain threshold results, the datafor the two agomelatine groups were found to be higher than control group at both time points. In 30th minute measurements, between Group B and the other groups, significant differences were observed (p=0.007). In addition, significance in the interaction between time and group was observed (p=0.036).Conclusions: The results of the study suggest that agomelatine might have analgesic efficacy on the nociceptive system in mice.
Topics
- Circadian rhythm and melatonin
- Biofield Effects and Biophysics
- Complementary and Alternative Medicine Studies
Primary topic Circadian rhythm and melatonin