Article detail · 2022
Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes
Journal
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICSISSN 0739-1102
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2022
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Catalog match (ISSN) Journal of Biomolecular Structure and Dynamics
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Aldose reductase (AR) and sorbitol dehydrogenase (SDH) are important enzymes of the polyol pathway. In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) and usnic acid (UA) on purified AR and SDH enzymes were determined. These enzymes inhibition could be essential to prevent diabetic complications. AR and SDH enzymes were purified from sheep kidney. Then, VA, CA and UA were tested in various concentrations against these enzymes activity in vitro. KI values were found to be as 1.46 ± 0.04, 5.13 ± 0.25 and 11.71 ± 0.27 μΜ for VA, CA and UA, respectively, for AR. KI constants were found to be as 15.32 ± 0.34, 145.60 ± 2.17 and 213.40 ± 2.64 μΜ VA, CA and UA, respectively, for SDH. These findings indicate that VA, CA and UA could be useful in the treatment of diabetic complications.Communicated by Ramaswamy H. Sarma
Topics
Citations
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102 citations
OpenAlex cited_by_count (cache / database)
145 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
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