Article detail · 2015
Enantiospecific Synthesis of (R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid Using (S)-Serine as a Chiral Pool
YÖKSİS
OpenAlex
SJR Q2
JCR Q3
Citations 3
Percentile 56.3%
FWCI 0.16
- Year
- 2015
- ISSN
0018-019X- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
English (OpenAlex)
Abstract Starting from (S)‐serine, a new method was developed for the synthesis of the β‐amino acid part of sitagliptin in ten steps and with an overall yield of 30%. The crucial step of the synthesis was the ring opening of N‐ and O‐protected (R)‐aziridin‐2‐methanol with (2,4,5‐trifluorophenyl)magnesium bromide to give N‐ and O‐protected (R)‐2‐amino‐3‐(2,4,5‐trifluorophenyl)propan‐1‐ol.
Topics
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Analysis
- Carbohydrate Chemistry and Synthesis
Primary topic Synthesis and Catalytic Reactions