Article detail · 2021
Systems Analysis Reveals Ageing-Related Perturbations in Retinoids and Sex Hormones in Alzheimer\u2019s and Parkinson\u2019s Diseases
Journal
BiomedicinesISSN 2589-0042
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2021
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Biomedicines
- Catalog match (ISSN) iScience
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Neurodegenerative diseases, including Alzheimer's (AD) and Parkinson's diseases (PD), are complex heterogeneous diseases with highly variable patient responses to treatment. Due to the growing evidence for ageing-related clinical and pathological commonalities between AD and PD, these diseases have recently been studied in tandem. In this study, we analysed transcriptomic data from AD and PD patients, and stratified these patients into three subclasses with distinct gene expression and metabolic profiles. Through integrating transcriptomic data with a genome-scale metabolic model and validating our findings by network exploration and co-analysis using a zebrafish ageing model, we identified retinoids as a key ageing-related feature in all subclasses of AD and PD. We also demonstrated that the dysregulation of androgen metabolism by three different independent mechanisms is a source of heterogeneity in AD and PD. Taken together, our work highlights the need for stratification of AD/PD patients and development of personalised and precision medicine approaches based on the detailed characterisation of these subclasses.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
24 citations
OpenAlex cited_by_count (cache / database)
17 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Revealing the Molecular Mechanisms of Alzheimer's Disease Based on Network Analysis 2021
- Revealing the Molecular Mechanisms of Alzheimer’s Disease Based on Network Analysis 2021
- Revealing the Molecular Mechanisms of Alzheimer\u2019s Disease Based on Network Analysis 2021
- Systems Biology Approaches to Decipher the Underlying Molecular Mechanisms of Glioblastoma Multiforme 2021
- Systems Biology Approaches to Decipher the Underlying Molecular Mechanisms of Glioblastoma Multiforme 2021
- Novel drug targets and molecular mechanisms for sarcopenia based on systems biology 2024
- The role of SIRT2 inhibition on the aging process of brain in male rats 2023
- The role of SIRT2 inhibition on the aging process of the brain in male rats 2023
- The role of SIRT2 inhibition on the aging process of brain in male rats 2023
- In vivo and in silico models of Drosophila for Parkinsons disease 2025