Article detail · 2023
Synthesis and Biological Activity of Some Bromophenols and Their Derivatives Including Natural Products
Journal
Chemistry & BiodiversityISSN 1612-1872
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2023
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Chemistry & Biodiversity
- Catalog match (ISSN) Chemistry and Biodiversity
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Abstract In addition to the first synthesis of the natural bromophenol butyl 2‐(3,5‐dibromo‐4‐hydroxyphenyl)acetate (1), indene derivatives 34 and 35 were synthesized from 3‐phenylpropenal derivatives in BBr3 medium. Five known natural bromophenols and some derivatives were synthesized by known methods. Cholinesterase (ChEs) inhibitors reduce the breakdown of acetylcholine and are used in the treatment of Alzheimer's disease (AD) and dementia symptoms. The inhibition effects of all obtained compounds were examined towards acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and α‐glycosidase enzymes. All synthesized compounds demonstrated the strong inhibition effects against both cholinergic enzymes. For determination of Ki values of novel bromophenols Lineweaver‐Burk graphs were obtained. Ki values were found in the ranging of 0.13–14.74 nM for AChE, 5.11–23.95 nM for BChE, and 63.96–206.78 nM for α‐glycosidase, respectively. All bromophenols and their derivatives exhibit effective inhibition profile when compared to positive controls.
Topics
Citations
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17 citations
OpenAlex cited_by_count (cache / database)
25 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
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- Novel composite structures based on cobalt phthalocyanine/graphene oxide: Identification of potential drug candidates to treat Alzheimer’s disease and diabetes 2024
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