Article detail · 2019
Synthesis and Antifungal Potential of Some Novel Benzimidazole-1,3,4-Oxadiazole Compounds
- Year
- 2019
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Molecules
- Catalog match (ISSN) Molecules
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Discovery of novel anticandidal agents with clarified mechanisms of action, could be a rationalist approach against diverse pathogenic fungal strains due to the rise of resistance to existing drugs. In support to this hypothesis, in this paper, a series of benzimidazole-oxadiazole compounds were synthesized and subjected to antifungal activity evaluation. In vitro activity assays indicated that some of the compounds exhibited moderate to potent antifungal activities against tested Candida species when compared positive control amphotericin B and ketoconazole. The most active compounds 4h and 4p were evaluated in terms of inhibitory activity upon ergosterol biosynthesis by an LC-MS-MS method and it was determined that they inhibited ergosterol synthesis concentration dependently. Docking studies examining interactions between most active compounds and lanosterol 14-α-demethylase also supported the in vitro results.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
77 citations
OpenAlex cited_by_count (cache / database)
50 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives 2019
- Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives 2019
- Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives 2019
- Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives 2019
- Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives 2019
- Synthesis, molecular modeling, quantum mechanical calculations and ADME estimation studies of benzimidazole-oxadiazole derivatives as potent antifungal agents 2022
- Synthesis, Molecular Docking, Dynamics, Quantum-Chemical Computation, and Antimicrobial Activity Studies of Some New Benzimidazole–Thiadiazole Hybrids 2022
- Synthesis, molecular modeling, quantum mechanical calculations and ADME estimation studies of benzimidazole-oxadiazole derivatives as potent antifungal agents 2022
- Synthesis, Molecular Modeling, Quantum Mechanical Calculations and ADME Estimation Studies of Benzimidazole-Oxadiazole Derivatives as Potent Antifungal Agents 2021
- Benzimidazole and Benzoxazole Derivatives Against Alzheimer's Disease 2024