Article detail · 2021
Transition\u2010Metal Complexes of Bidentate Schiff\u2010Base Ligands: In Vitro and In Silico Evaluation as Non\u2010Classical Carbonic Anhydrase and Potential Acetylcholinesterase Inhibitors
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- 2021
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- article
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Abstract
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Aldose reductase (AR) and sorbitol dehydrogenase (SDH) are important enzymes of the polyol pathway. In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) and usnic acid (UA) on purified AR and SDH enzymes were determined. These enzymes inhibition could be essential to prevent diabetic complications. AR and SDH enzymes were purified from sheep kidney. Then, VA, CA and UA were tested in various concentrations against these enzymes activity in vitro. KI values were found to be as 1.46 ± 0.04, 5.13 ± 0.25 and 11.71 ± 0.27 μΜ for VA, CA and UA, respectively, for AR. KI constants were found to be as 15.32 ± 0.34, 145.60 ± 2.17 and 213.40 ± 2.64 μΜ VA, CA and UA, respectively, for SDH. These findings indicate that VA, CA and UA could be useful in the treatment of diabetic complications.Communicated by Ramaswamy H. Sarma
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102 citations
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154 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
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