Article detail · 2019
Analysis of DNA protection, interaction and antimicrobial activity of isatin derivatives
- Year
- 2019
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue International Journal of Biological Macromolecules
- Catalog match (ISSN) International Journal of Biological Macromolecules
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
The ultimate aim of this study is to produce a composite of bimetallic platinum-cobalt nanoparticles and reduced graphene oxide (Pt-Co@rGO) based biosensor for the detection of ascorbic acid (AA), dopamine (DA) and uric acid (UA). Those are biologically important molecules with the key functions for the human body. Pt-Co@rGO was synthesized using a microwave-assisted technique and utilized for the production of a highly sensitive and stable electrochemical biosensor. Detailed spectral XPS and Raman analysis, XRD, and TEM/HR-TEM characterization were also studied. Due to the superior activity and excellent conductivity of rGO, well-separated oxidation peaks of these biomolecules is proven by DPV (differential pulse voltammetry) and CV (cyclic voltammetry) measurements. The prepared Pt-Co@rGO-based biosensor showed high electrochemical activity, a broad linear response, high sensitivity, and acceptable limit of detection values for individual and simultaneous determination of AA, DA, and UA, under optimized conditions. The linear range of Pt-Co@rGO was found to be 170-200; 35-1500 and 5-800 µM for AA, DA, and UA, respectively. Moreover, the detection limit of the prepared composite was calculated as 0.345; 0.051; 0.172 µM for AA, DA, and UA, respectively. In the field of electrochemical biosensors, Pt-Co@rGO based sensor is highly promising due to its superior sensitivity and good selectivity properties.
Topics
Citations
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90 citations
OpenAlex cited_by_count (cache / database)
35 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
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