Article detail · 2021
Is sitagliptin effective for the treatment of COVID-19?
- Year
- 2021
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue European Journal of Hospital Pharmacy
- Catalog match (ISSN) European Journal of Hospital Pharmacy
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
English (OpenAlex)
Cluster of differantiation 26 (CD26) plays an important role in chronic graft versus host disease (GVHD), psoriasis, diabetes, haematological and solid cancers. In addition, S1, the spike protein of Middle East respiratory syndrome coronavirus, has been shown to enter human host cells using CD26, also known as dipeptidyl peptidase-4 (DPP-4), as a functional receptor.1 In a molecular docking study, it was determined that the S1 domain of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein could potentially interact with CD26, an important immunoregulatory factor for hijacking and virulence.2 In a retrospective observational case-control study, 338 patients with type 2 diabetes and coronavirus disease 2019 (COVID-19) were matched 1:1 for age and gender. …
Topics
- Peptidase Inhibition and Analysis
- Neuropeptides and Animal Physiology
- Neuroendocrine Tumor Research Advances
Primary topic Peptidase Inhibition and Analysis