Antioxidant Effects of Styrax Liquidus on DMBA-exposed Rat Tongue Tissues

English (OpenAlex)

Objective: Natural products with antioxidant components are believed to have a strong potential in prevention of cancer and some degenerative diseases.Liquidambar orientalis Miller (Styrax liquidus) is known to have strong in vitro antioxidant activity.The purpose was to evaluate the effects of Styrax liquidus on the antioxidant defense mechanisms in 7,12-dimethylbenz(a)anthracene (DMBA)-applied rat tongue tissues. Materials and Methods:Wistar rats (n=30) were randomly divided into Control, DMBA, DMBA+SL and SL groups.Control group was treated with liquid paraffin only, DMBA group was treated with 0.5% DMBA, DMBA and Styrax liquidus were applied to DMBA + SL group, and only Styrax liquidus was applied to SL group.All applications were made to the oral mucosa.16 weeks later, tongue tissues of all animals were removed.Superoxide dismutase, catalase, glutathione peroxidase enzyme activities, and malondialdehyde and total antioxidant status levels were measured.Results: All parameters were significantly lower in the SL+DMBA group.Antioxidant enzyme activities and oxidative stress parameters were lowered in the SL+DMBA and SL groups.SL+DMBA application is believed to have an inhibitory effect on the antioxidant enzymes measured in this study; however, the decrease in malondialdehyde levels (lipid peroxidation marker) highlights the antioxidant effect of Styrax liquidus in 7,12-dimethylbenz(a)anthracene-exposed rat tongue tissues.Conclusion: Styrax liquidus exhibited in vivo antioxidant activity in an oral cancer model in this study.Further research may be useful in understanding the exact mechanisms of this effect.