Article detail · 2009
Transcriptional neoteny in the human brain
Journal
Proceedings of the National Academy of SciencesISSN 0027-8424
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2009
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue Proceedings of the National Academy of Sciences
- Catalog match (ISSN) Proceedings of the National Academy of Sciences of the United States of America
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
In development, timing is of the utmost importance, and the timing of developmental processes often changes as organisms evolve. In human evolution, developmental retardation, or neoteny, has been proposed as a possible mechanism that contributed to the rise of many human-specific features, including an increase in brain size and the emergence of human-specific cognitive traits. We analyzed mRNA expression in the prefrontal cortex of humans, chimpanzees, and rhesus macaques to determine whether human-specific neotenic changes are present at the gene expression level. We show that the brain transcriptome is dramatically remodeled during postnatal development and that developmental changes in the human brain are indeed delayed relative to other primates. This delay is not uniform across the human transcriptome but affects a specific subset of genes that play a potential role in neural development.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
432 citations
OpenAlex cited_by_count (cache / database)
14 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- A Draft Sequence of the Neandertal Genome 2010
- MicroRNA mRNA and protein expression link development and aging in human and macaque brain 2010
- Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques 2012
- Human brain evolution transcripts metabolites and their regulators 2013
- MicroRNA Driven Developmental Remodeling in the Brain Distinguishes Humans from Other Primates 2011
- Disruption of an Evolutionarily Novel Synaptic Expression Pattern in Autism 2016
- Gene expression reversal toward pre-adult levels in the aging human brain and age-related loss of cellular identity 2017
- Gene expression reversal toward pre-adult levels in the aging human brain and age-related loss of cellular identity 2017
- Gene expression reversal toward pre-adult levels in the aging human brain and age-related loss of cellular identity 2017
- Transcriptomic insights into human brain evolution acceleration neutrality heterochrony 2014