Article detail · 2018
Antimicrobial Activities of New Indole Derivatives Containing 1,2,4-Triazole, 1,3,4-Thiadiazole and Carbothioamide
Journal
The Turkish Journal of Pharmaceutical SciencesISSN 1304-530X
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2018
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue The Turkish Journal of Pharmaceutical Sciences
- Catalog match (ISSN) Turkish Journal of Pharmaceutical Sciences
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
English (OpenAlex)
OBJECTIVES: In new antimicrobial drug development studies, indole and its derivatives create an important class of compounds. In addition, azoles and their derivatives were recognized to be associated with a variety of biologic activities such as antibacterial and antifungal. In this study antimicrobial activities of some indole derivatives mainly substituted with 1,2,4-triazole, 1,3,4-thiadiazole and hydrazinecarbothioamide were investigated to evaluate their efficacy. MATERIALS AND METHODS: . RESULTS: The MIC was determined for test compounds and for the reference standards sultamicillin, ampicillin, fluconazole, and ciprofloxacin. CONCLUSION: The compounds possessed a broad spectrum of activity having MIC values of 3.125-50 µg/mL against the tested microorganisms. This study provides valuable evidence that the indole-triazole derivative compound 3d holds significant promise as a novel antibacterial and antifungal lead compound.
Topics
- Synthesis and biological activity
- Synthesis of Tetrazole Derivatives
- Click Chemistry and Applications
Primary topic Synthesis and biological activity