Article detail · 2016
Effectiveness of sugammadex for cerebral ischemia reperfusion injury
Journal
The Kaohsiung Journal of Medical SciencesISSN 1607-551X
The ISSN points to another catalog journal; the name is from the YÖKSİS record.
- Year
- 2016
- Type
- article
Data source split
- YÖKSİS YÖKSİS article record
- YÖKSİS venue The Kaohsiung Journal of Medical Sciences
- Catalog match (ISSN) Kaohsiung Journal of Medical Sciences
- OpenAlex OpenAlex enrichment (abstract, citations, topics)
Abstract
OpenAlex · English
Cerebral ischemia may cause permanent brain damage and behavioral dysfunction. The efficacy and mechanisms of pharmacological treatments administered immediately after cerebral damage are not fully known. Sugammadex is a licensed medication. As other cyclodextrins have not passed the necessary phase tests, trade preparations are not available, whereas sugammadex is frequently used in clinical anesthetic practice. Previous studies have not clearly described the effects of the cyclodextrin family on cerebral ischemia/reperfusion (I/R) damage. The aim of this study was to determine whether sugammadex had a neuroprotective effect against transient global cerebral ischemia. Animals were assigned to control, sham-operated, S 16 and S 100 groups. Transient global cerebral ischemia was induced by 10-minute occlusion of the bilateral common carotid artery, followed by 24-hour reperfusion. At the end of the experiment, neurological behavior scoring was performed on the rats, followed by evaluation of histomorphological and biochemical measurements. Sugammadex 16 mg/kg and 100 mg/kg improved neurological outcome, which was associated with reductions in both histological and neurological scores. The hippocampus TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) and caspase results in the S 16 and S 100 treatment groups were significantly lower than those of the I/R group. Neurological scores in the treated groups were significantly higher than those of the I/R group. The study showed that treatment with 16 mg/kg and 100 mg/kg sugammadex had a neuroprotective effect in a transient global cerebral I/R rat model. However, 100 mg/kg sugammadex was more neuroprotective in rats.
Topics
Citations
OpenAlex cited_by_count. Not a WoS or Scopus citation count; those sources have no separate column here.
20 citations
OpenAlex cited_by_count (cache / database)
40 publications in the local catalog that cite this work (OpenAlex reference match; not the full global list).
- Investigation of the effect of sugammadex on glutamate‐induced neurotoxicity in C6 cell line and the roles played by nitric oxide and oxidative stress pathways 2023
- Investigation of the effect of sugammadex on glutamateinduced neurotoxicity in C6 cell line and the roles played by nitric oxide and oxidative stress pathways 2023
- Comparison of the cytotoxic, genotoxic and apoptotic effects of Sugammadex and Neostigmine on human embryonic renal cell (HEK-293). 2018
- Comparison of the cytotoxic, genotoxic and apoptotic effects of Sugammadex and Neostigmine on human embryonic renal cell (HEK-293) 00 2018
- Comparison of the cytotoxic, genotoxic and apoptotic effects of Sugammadex and Neostigmine on human embryonic renal cell (HEK-293) 2018
- Evaluation of Neuroprotective Effects of Sugammadex Following a Head Trauma in an Experimental Study 2022
- Evaluation of Neuroprotective Effects of Sugammadex Following a Head Trauma in an Experimental Study 2022
- Evaluation of Neuroprotective Effects of Sugammadex Following a Head Trauma in an Experimental Study 2022
- Evaluation of Neuroprotective Effects of Sugammadex Following a Head Trauma in an Experimental Study 2022
- Evaluation of Neuroprotective Effects of Sugammadex Following a Head Trauma in an Experimental Study 2022