Is it possible to predict the spontaneous reduction of pediatric intussusception using biomarkers?

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BACKGROUND: Intussusception is one of the most common causes of acute abdominal pain in childhood. In this study, we hypothesized that alpha-glutathione S-transferase (alpha-GST), intestinal fatty acid-binding protein (IFAB), and inflammatory markers may predict spontaneous reduction in ileocolic intussusceptions, thereby preventing unnecessary interventions. METHODS: A single-center, prospective case-control study was conducted in the Pediatric Emergency Department. Patients with ileocolic intussusception were categorized into three subgroups: spontaneous reduction, hydrostatic reduction, and those requiring surgery. Levels of Alpha-GST, IFABP, and routine inflammatory markers were measured prior to intervention. RESULTS: A total of 52 cases of intussusception and 26 control patients were included in the study. Spontaneous reduction occurred in seven patients, while 45 patients required intervention. A statistically significant difference was observed between the patient and control groups regarding Alpha-GST, C-reactive protein (CRP), white blood cell count, neutrophil count, and the neutrophil-to-lymphocyte ratio (NLR). However, IFABP did not show a statistically significant difference. Alpha-GST, NLR, and CRP levels were significantly higher in the group requiring intervention than in the spontaneous reduction group. CONCLUSION: This study demonstrates that Alpha-GST, NLR, and CRP may predict spontaneous reduction in cases of intussusception and thereby minimize the need for unnecessary interventions.