Advanced Glycation End Products research

D iabetes mellitus is a chronic metabolic disease with substantial morbidity that requires lifelong management.It encompasses Type 1 diabetes (autoimmune β-cell destruction), Type 2 diabetes (insulin resistance with relative insulin deficiency), and gestational diabetes (hyperglycemia first recognized in pregnancy, wh…

• METİN DEMİREL

Aims: Increasing evidence suggests that cardiovascular disease risk increases in metabolic dysfunction-associated steatotic liver disease (MASLD). Fetuin-A, reseptor for advanced glycation end-products (RAGE) and fibroblast growth factor 23 (FGF-23) are associated with insulin resistance (IR), inflammation, oxidative…

Background: Diabetes Mellitus (DM) and Urinary Tract Infections (UTIs) are common conditions that, especially when occurring together, lead to significant morbidity. This study aimed to investigate the effects of Ciprofloxacin (CIP) treatment on oxidative stress, antioxidant defense systems, and inflammatory markers i…

Harnessing fungal lignocellulose-degrading enzymes offers sustainable pathways for converting biomass into value-added chemicals. Glyoxal oxidases (GLOX), copper metalloenzymes involved in lignin degradation, can catalyze the oxidation of several furan derivatives into 2,5-furandicarboxylic acid (FDCA), a bioplastic p…

extract demonstrated contrasting regulatory profiles, which exhibited a broader modulation of endoplasmic reticulum stress and mitogen-activated protein kinase signaling. Collectively, the findings demonstrate that ESF selectively attenuates inflammatory and angiogenic responses by specifically inhibiting the NF-κB-VE…

Age-related macular degeneration (AMD) and diabetic retinopathy (DR) constitute leading causes of irreversible visual impairment; both are pathologically linked to chronic inflammation and endoplasmic reticulum (ER) stress in retinal pigment epithelial (RPE) cells. This study aimed to investigate the protective effect…

The global prevalence of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) is increasing significantly in an age-dependent manner. Growing evidence supports the conceptualization of AD as 'type 3 diabetes,' a term proposed to describe a metabolic disease primarily driven by impaired insulin signalling and i…

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OBJECTIVE: The aim of this study was to evaluate the association between oxidative stress and cervical human papillomavirus infection and cervical intraepithelial neoplasia by measuring total oxidant status, total antioxidant status, and ischemia-modified albumin levels. METHODS: In total, 50 human papillomavirus+ wom…

ObjectiveDiabetic nephropathy (DN) remains one of the mostserious complications of type 2 diabetes mellitus(T2DM). Traditionally, disease progression hasbeen evaluated through albuminuria, yet increasingevidence highlights the role of oxidative stress andredox imbalance in DN pathogenesis. The presentstudy was designe…