Makale detayı · 2010
A General Mechanism for Network-Dosage Compensation in Gene Circuits
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Science- Yıl
- 2010
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- article
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- YÖKSİS dergi adı Science
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Özet
OpenAlex · İngilizce
Coping with variations in network dosage is crucial for maintaining optimal function in gene networks. We explored how network structure facilitates network-level dosage compensation. By using the yeast galactose network as a model, we combinatorially deleted one of the two copies of its four regulatory genes and found that network activity was robust to the change in network dosage. A mathematical analysis revealed that a two-component genetic circuit with elements of opposite regulatory activity (activator and inhibitor) constitutes a minimal requirement for network-dosage invariance. Specific interaction topologies and a one-to-one interaction stoichiometry between the activating and inhibiting agents were additional essential elements facilitating dosage invariance. This mechanism of network-dosage invariance could represent a general design for gene network structure in cells.
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Yerel katalogda bu makaleye atıf yapan 13 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
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- Evolution of gene network activity by tuning the strength of negative-feedback regulation 2015
- Noise reduction as an emergent property of single-cell aging 2017
- The Systems Biology of Single-Cell Aging 2018
- Insights into Bidirectional Gene Expression Control Using the Canonical GAL1/GAL10 Promoter 2018
- Noise reduction facilitated by dosage compensation in gene networks 2016
- Epigenetic Mechanisms Contribute to Evolutionary Adaptation of Gene Network Activity under Environmental Selection 2020
- A cell size- and cell cycle-aware stochastic model for predicting time-dynamic gene network activity in individual cells 2015
- Network-dosage compensation topologies as recurrent network motifs in natural gene networks 2014
- A Precise Genome Editing Method Reveals Insights into the Activity of Eukaryotic Promoters 2017