Makale detayı · 2016
Noise reduction facilitated by dosage compensation in gene networks
Dergi
Nature Communications- Yıl
- 2016
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS dergi adı Nature Communications
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
Genetic noise together with genome duplication and volume changes during cell cycle are significant contributors to cell-to-cell heterogeneity. How can cells buffer the effects of these unavoidable epigenetic and genetic variations on phenotypes that are sensitive to such variations? Here we show that a simple network motif that is essential for network-dosage compensation can reduce the effects of extrinsic noise on the network output. Using natural and synthetic gene networks with and without the network motif, we measure gene network activity in single yeast cells and find that the activity of the compensated network is significantly lower in noise compared with the non-compensated network. A mathematical analysis provides intuitive insights into these results and a novel stochastic model tracking cell-volume and cell-cycle predicts the experimental results. Our work implies that noise is a selectable trait tunable by evolution.
Konular
Atıflar
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27 atıf
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Yerel katalogda bu makaleye atıf yapan 8 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
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- The Systems Biology of Single-Cell Aging 2018
- Insights into Bidirectional Gene Expression Control Using the Canonical GAL1/GAL10 Promoter 2018
- Phenotypic plasticity as a facilitator of microbial evolution 2022
- Epigenetic Mechanisms Contribute to Evolutionary Adaptation of Gene Network Activity under Environmental Selection 2020
- Modeling aging and its impact on cellular function and organismal behavior 2021
- Multi-component gene network design as a survival strategy in diverse environments 2018
- Chromatin regulatory genes differentially interact in networks to facilitate distinct GAL1 activity and noise profiles 2021