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Makale detayı · 1996

Genetic Susceptibility to Leishmania : IL-12 Responsiveness in T H 1 Cell Development

Dergi

Science
OpenAlex SJR Q1 JCR Q1 Atıf 366 Üst %1 Yüzdelik 100.0% FWCI 78.62
Yıl
1996
DOI
10.1126/science.271.5251.984
Tür
article

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Özet

OpenAlex · İngilizce

The genetic background of T lymphocytes influences development of the T helper (TH) phenotype, resulting in either resistance or susceptibility of certain mouse strains to pathogens such as Leishmania major. With an in vitro model system, a difference in maintenance of responsiveness of T cells to interleukin-12 (IL-12) was detected between BALB/c and B10.D2 mice. Although naive T cells from both strains initially responded to IL-12, BALB/c T cells lost IL-12 responsiveness after stimulation with antigen in vitro, even when cocultured with B10.D2 T cells. Thus, susceptibility of BALB/c mice to infection with L. major may derive from the loss of the ability to generate IL-12-induced TH1 responses rather than from an IL-4-induced TH2 response.

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Atıflar

OpenAlex cited_by_count. WoS veya Scopus atıf sayısı değildir; o kaynaklar için ayrı kolon yoktur.

366 atıf

OpenAlex cited_by_count (önbellek / veritabanı)

Yerel katalogda bu makaleye atıf yapan 12 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).

  1. Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses. 1996 Atıf 203 · OpenAlex
  2. Low dose TGF-beta attenuates IL-12 responsiveness in murine Th cells. 1998 Atıf 117 · OpenAlex
  3. Low Dose TGF-β Attenuates IL-12 Responsiveness in Murine Th Cells 1998 Atıf 97 · OpenAlex
  4. T Helper Differentiation Proceeds Through Stat1-Dependent, Stat4-Dependent and Stat4-Independent Phases 1999 Atıf 78 · OpenAlex
  5. Tpm1, a Locus Controlling IL-12 Responsiveness, Acts by a Cell-Autonomous Mechanism 1999 Atıf 41 · OpenAlex
  6. Regulation of IL-12 Receptor Expression in Early T-Helper Responses Implies Two Phases of Th1 Differentiation: Capacitance and Development 1997 Atıf 21 · OpenAlex
  7. Loci influencing development of Th responses. Identification from in vitro analysis 1999 Atıf 7 · OpenAlex
  8. Anti-Inflammatory Potential of Pre-Formulated Aloe vera in Mitigating Allergen-Induced Airway Responses in Mice 2025 Atıf 0 · OpenAlex
  9. Anti-inflammatory potential of pre-formulated Aloe vera in mitigating allergen-induced airway responses in mice 2025 Atıf 0 · OpenAlex
  10. Anti-inflammatory potential of pre-formulated Aloe vera in mitigating allergen-induced airway responses in mice 2025 Atıf 0 · OpenAlex

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