Makale detayı · 1996
Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses.
Dergi
Proceedings of the National Academy of Sciences- Yıl
- 1996
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS dergi adı Proceedings of the National Academy of Sciences
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
Genetic background of the T cell can influence T helper (Th) phenotype development, with some murine strains (e.g., B10.D2) favoring Th1 development and others (e.g., BALB/c) favoring Th2 development. Recently we found that B10.D2 exhibit an intrinsically greater capacity to maintain interleukin 12 (IL-12) responsiveness under neutral conditions in vitro compared with BALB/c T cells, allowing for prolonged capacity to undergo IL-12-induced Th1 development. To begin identification of the loci controlling this genetic effect, we used a T-cell antigen receptor-transgenic system for in vitro analysis of intercrosses between BALB/c and B10.D2 mice and have identified a locus on murine chromosome 11 that controls the maintenance of IL-12 responsiveness, and therefore the subsequent Th1/Th2 response. This chromosomal region is syntenic with a locus on human chromosome 5q31.1 shown to be associated with elevated serum IgE levels, suggesting that genetic control of Th1/Th2 differentiation in mouse, and of atopy development in humans, may be expressed through similar mechanisms.
Konular
Atıflar
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203 atıf
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Yerel katalogda bu makaleye atıf yapan 8 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
- Low dose TGF-beta attenuates IL-12 responsiveness in murine Th cells. 1998
- Low Dose TGF-β Attenuates IL-12 Responsiveness in Murine Th Cells 1998
- T Helper Differentiation Proceeds Through Stat1-Dependent, Stat4-Dependent and Stat4-Independent Phases 1999
- Two Autoimmune Diabetes Loci Influencing T Cell Apoptosis Control Susceptibility to Experimental Autoimmune Myocarditis 2005
- Tpm1, a Locus Controlling IL-12 Responsiveness, Acts by a Cell-Autonomous Mechanism 1999
- Genetic control of Interleukin 12 responsiveness: implications for disease pathogenesis 1997
- A locus on chromosome 1 promotes susceptibility of experimental autoimmune myocarditis and lymphocyte cell death 2008
- Loci influencing development of Th responses. Identification from in vitro analysis 1999