The Effects of Allium Czelghauricum (Liliaceae), Lathyrus Karsianus (Fabaceae) and Onosma Nigricaule (Boraginaceae) Extracts on Oxidation Parameters in Malathion Treated Mice

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Aim: It was aimed to determine antioxidant properties of extracts obtained from Allium czelghauricum, Lathyrus karsianus and Onosma nigricaule species and antioxidant effects of plant extracts on malathion-induced oxidant parameters in mice.Material and Method: Expermental animals were seperated into ten groups, each consisting of ten mice.First group was designed as a control group.Second group received 0.2 mL/kg of saline, and third group received the same dose of corn oil.Fourth (100 mg/kg malathion), fifth (100 mg/kg Allium czelghauricum), sixth (100 mg/kg Lathyrus karsianus), seventh (100 mg/kg Onosma nigricaule), eighth (100 mg/kg malathion+100 mg/kg Allium czelghauricum), ninth (100 mg/kg malathion+100 mg/kg Lathyrus karsianus) and the tenth group (100 mg/kg malathion+100 mg/kg Onosma nigricaule) were given daily intraperitoneally in the determined amounts.Applications were made for 21 days.After administration, total oxidant and total antioxidant capacities, body and liver weights, and histopathological changes in the liver were investigated in the serum and liver of mice.Results: It is observed that plant extracts significantly inhibit the dose dependent concentrations of nitric oxide radical.A high amount of polyphenolic compounds were detected in plant extracts.While applied malathion mice weighed lighter, an increase in their liver was observed.Pathological changes were found in the liver of mice given malathion in histopalogical examinations.Total oxidant capacity (TOC) of serum and liver was significantly higher compared with control group; however, a decrease was observed in total antioxidant capacity (TAC).While the TOC in the serum and liver of mice given malathion and plant extract decreased compared to the malathion group, it was found that there was an increase in TAC.Conclusion: In vitro study, it was revealed that methanol extracts of plants have antioxidant effects.In addition, it was determined that plant extracts exhibited antioxidant effects against the oxidant effect caused by malathion.