Makale detayı · 2026
Wound healing activities of eucalyptol on full thickness excisional skin wound model in rats
Dergi
Ankara Üniversitesi Veteriner Fakültesi DergisiISSN 1300-0861
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- Yıl
- 2026
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- YÖKSİS dergi adı Ankara Üniversitesi Veteriner Fakültesi Dergisi
- Katalog eşleşmesi (ISSN) Ankara Universitesi Veteriner Fakultesi Dergisi
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
A plant-derived monoterpene, eucalyptol (1,8-cineole), has been suggested to have antioxidant, anti-inflammatory, and antimicrobial properties. The wound-healing effects of eucalyptol remain unknown. This study aimed to evaluate the topical use of eucalyptol at two concentrations on a full-thickness excisional skin wound model in terms of wound healing, gene expression, biochemical changes, and histopathological changes. Sixty Wistar rats were randomly divided into 5 groups (n = 12 per group). The control group (C) was untreated. Full-thickness excisional skin wounds were created in the following groups: the vehicle group (V), which was treated with polysorbate 80 solution (negative control). The Dexpanthenol group (D) was treated with dexpanthenol ointment (positive control). Eucalyptol 5% (E5) and Eucalyptol 10% (E10) groups were treated with 5% and 10% eucalyptol, respectively. Wound areas were measured on days 1, 4, 7, 11, 14, 18, and 21 days after wound creation. Wound tissues were collected on days 7 and 21. Histopathological, gene expression (TNFα, IL10, TGFβ1, VEGF), and biochemical (MDA, rGSH, GPx, CAT) analyses were performed on the wound tissues. TNFα gene expression levels were upregulated in Groups V and E5 (P
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Yerel katalogda bu makaleye atıf yapan 3 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
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