Makale detayı · 2016
Tympanic Membrane Perforation Caused by Thunderbolt Strike
- Yıl
- 2016
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- YÖKSİS dergi adı Journal of Craniofacial Surgery
- Katalog eşleşmesi (ISSN) Journal of Craniofacial Surgery
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
The genetics of both syndromic (SHL) and non-syndromic hearing loss (NSHL) is characterized by a high degree of genetic heterogeneity. We analyzed whole exome sequencing data of 102 unrelated probands with apparently NSHL without a causative variant in known NSHL genes. We detected five causative variants in different SHL genes (SOX10, MITF, PTPN11, CHD7, and KMT2D) in five (4.9%) probands. Clinical re-evaluation of these probands shows that some of them have subtle syndromic findings, while none of them meets clinical criteria for the diagnosis of the associated syndrome (Waardenburg (SOX10 and MITF), Kallmann (CHD7 and SOX10), Noonan/LEOPARD (PTPN11), CHARGE (CHD7), or Kabuki (KMT2D). This study demonstrates that individuals who are evaluated for NSHL can have pathogenic variants in SHL genes that are not usually considered for etiologic studies.
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Yerel katalogda bu makaleye atıf yapan 12 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
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- Novel EYA1 variants causing Branchio-oto-renal syndrome 2017
- Novel EYA1 variants causing Branchio-oto-renal syndrome 2017
- Dysfunction of iGRAP/i , encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss/title 2019
- Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss 2019
- Biallelic KITLG variants lead to a distinct spectrum of hypomelanosis and sensorineural hearing loss 2022
- Biallelic KITLG variants lead to a distinct spectrum of hypomelanosis and sensorineural hearing loss 2022
- Identification of novel MYH14 variants in families with autosomal dominant sensorineural hearing loss 2024