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Article detail · 2025

Evaluation of Cytomegalovirus Seroprevalence in Pregnant Women: A Multicenter Study

Mediterranean Journal of Infection Microbes and Antimicrobials

YÖKSİS OpenAlex ISSN 2147-673X DOI 10.4274/mjima.galenos.2025.25310.11 Citations 1 Open access · diamond SJR Q4 TR Index

10.4274/mjima.galenos.2025.25310.11

YÖKSİS YÖKSİS article record

OpenAlex OpenAlex enrichment (abstract, citations, topics)

Abstract

OpenAlex record

English (OpenAlex)

Introduction: Cytomegalovirus (CMV) infection during pregnancy poses a significant risk of congenital infection, particularly in seronegative women.This study aimed to assess CMV seroprevalence among pregnant women and evaluate the incidence of primary CMV infections during pregnancy. Materials and Methods:This retrospective multicenter study included pregnant women aged ≥18 year who were hospitalized between January 2018 and December 2022.Demographic data -including maternal age, gravidity, and educational and occupational status -along with CMV serological results, gestational age at CMV diagnosis, and fetal ultrasonographic (USG) findings were collected and analyzed.In cases with positive CMV immunoglobulin M (IgM) and IgG, CMV-IgG avidity values, amniotic fluid CMV-DNA polymerase chain reaction results, and fetal USG findings were recorded to assess the likelihood of primary infection.Results: Among 16,761 pregnant women, 261 (1.6%) tested positive for CMV-IgM.Of these, 126 (48.3%) underwent CMV-IgG avidity testing, and three cases demonstrated low avidity, indicating recent primary infection.Ultrasonographic abnormalities in these three fetuses included hydrops fetalis, polyhydramnios, skin edema, and hyperechogenic bowel.Additionally, five patients with high CMV-IgG levels underwent IgG avidity testing; fetal USG findings in these cases revealed intrauterine growth restriction, oligohydramnios, and cranial abnormalities.Conclusion: Primary CMV infection during pregnancy is associated with adverse outcomes such as fetal anomalies, spontaneous abortion, and preterm birth.Preventive strategies, including educating CMV-seronegative women about transmission routes and routine assessment of CMV-IgG avidity and fetal USG findings, are essential for early diagnosis and improved perinatal outcomes.

OpenAlex enrichment

Topics

  • Cytomegalovirus and herpesvirus research

Type: article Cytomegalovirus and herpesvirus research

Index information

WoS (JCR) and Scopus (SJR) quartiles by ISSN and publication year. · 2025

Scopus (SJR) / WoS (JCR)

Mediterranean Journal of Infection, Microbes and Antimicrobials

Scopus (SJR) Q4 0,189 Year 2025

TR Index

Mediterranean journal of infection, microbes & antimicrobials (Online)

TR Index years 2023–2026 (4)

Article year is within TR Index coverage.

Universities

  • SİİRT ÜNİVERSİTESİ

Authors

  1. MERVE SEFA SAYAR
  2. YASEMİN ÇAĞ
  3. NEZİHA YILMAZ
  4. SENİHA ŞENBAYRAK
  5. TUBA DAMAR ÇAKIRCA
  6. Özge Çaydaşı
  7. Deniz ür Altunay
  8. ESRA ERDEM KIVRAK
  9. DENİZ ÖZER
  10. ESMA ERYILMAZ EREN
  11. FİSUN VURAL
  12. SEVİL ALKAN
  13. RAMAZAN GÖZÜKÜÇÜK
  14. FİRDEVS AKSOY
  15. DİLŞAT TEPE
  16. FATMA YEKTA ÜRKMEZ
  17. MEHMET UÇAR
  18. SERPİL MIZRAKÇI
  19. ÖZLEM AYDIN
  20. ARZU ŞENOL
  21. EMİNE KÜBRA DİNDAR SİİRT ÜNİVERSİTESİ