Makale detayı · 2022
Memory B cells and serum immunoglobulins are associated with disease severity and mortality in patients with COVID-19
- Yıl
- 2022
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- YÖKSİS dergi adı POSTGRADUATE MEDICAL JOURNAL
- Katalog eşleşmesi (ISSN) Postgraduate Medical Journal
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
PURPOSE OF THE STUDY: The aim of this study was to investigate the relationship of B cell-mediated immunity with disease severity and mortality in patients with COVID-19. STUDY DESIGN: In this retrospective cohort and single-centre study, 208 patients with laboratory-confirmed COVID-19 were recruited. A COVID-19 severity score, ranging from 0 to 10, was used to evaluate associations between various factors. Serum immunoglobulin levels and the number of cells in B lymphocyte subsets were measured and their association with disease severity and mortality in patients with COVID-19 examined. RESULTS: The median age of the patients was 50 (35-63) years and 88 (42%) were female. The number of deceased patients was 17. The median COVID-19 severity score was 8 (6-8) in deceased patients and 1 (0-2) in survivors. Deceased patients had significantly lower levels of total B lymphocytes, naive B cells, switched memory B cells, and serum IgA, IgG, IgG1 and IgG2 than recovered patients (all p<0.05). In addition, a significant negative correlation was found between the number of these parameters and COVID-19 severity scores. Decrease in the number of total B cells and switched memory B cells as well as lower serum IgA, IgG and IgG1 levels were independent risk factors for mortality in patients with COVID-19. CONCLUSION: In the present study, the prognosis of patients with COVID-19 was shown to be associated with the B cell subset and serum immunoglobulin levels.
Konular
Atıflar
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Yerel katalogda bu makaleye atıf yapan 5 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
- Clinical Importance of Immunophenotyping of Peripheral Blood Lymphocyte Subsets in Adult COVID-19 Patients: A Cross-Sectional Study 2023
- Clinical Importance of Immunophenotyping of Peripheral Blood Lymphocyte Subsets in Adult COVID-19 Patients: A Cross-Sectional Study 2023
- Clinical Importance of Immunophenotyping of Peripheral Blood Lymphocyte Subsets in Adult COVID-19 Patients: A Cross-Sectional Study 2023
- Clinical Importance of Immunophenotyping of Peripheral Blood Lymphocyte Subsets in Adult COVID-19 Patients: A Cross-Sectional Study 2023
- Clinical Importance of Immunophenotyping of Peripheral Blood Lymphocyte Subsets in Adult COVID-19 Patients: A Cross-Sectional Study 2023