Factors Affecting Mortality in Chronic Obstructive Lung Disease

English (OpenAlex)

Objective: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease causing inflammation and airflow limitation. COPD is a major cause of death worldwide. In Türkiye, COPD represents a significant health concern, ranking as the third leading cause of mortality. This study investigates factors predicting mortality in stable COPD patients. We aim to identify factors beyond respiratory function tests that can guide prognosis in these patients. Materials and Methods: We analyzed data from 75 deceased COPD patients and 98 age-matched living patients with COPD. Pulmonary function tests and blood tests were reviewed. Statistical analysis identified potential relationships between lung function, co-morbidities, and mortality in COPD. Results: While no significant differences in demographics (gender, age, smoking history, BMI) were found, lung function (%FEV1, %FVC, PEF, MEF25-75) was significantly associated with mortality in deceased patients. Deceased patients also had lower hemoglobin, hematocrit, and higher sedimentation/CRP levels. Eosinophil levels were significantly higher in living patients. Multivariate logistic regression analysis revealed heart failure and lung cancer as significant factors for COPD mortality. Discussion and Conclusion: This study investigated the factors predicting mortality in COPD. Elevated inflammatory markers in stable COPD patients suggested persistent inflammation. Our findings indicate that Pulmonary Function Tests, eosinophil count, hemoglobin, hematocrit, CRP, and sedimentation rate may be valuable predictors of mortality in these patients. These markers offer advantages due to their affordability, rapid accessibility, and practicality for follow-up.