Makale detayı · 2020
In vivo and in vitro anti‐diabetic activity of ethanolic propolis extract
- Yıl
- 2020
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- YÖKSİS dergi adı JOURNAL OF FOOD BIOCHEMISTRY
- Katalog eşleşmesi (ISSN) Journal of Food Biochemistry
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
Mad honey or rhododendron honey containing grayanotoxins possesses antioxidant and anti-inflammatory properties. This study was planned to evaluate the effects of topical application of mad honey on wound healing in diabetic rats. Dorsal skin wounds were created under anesthesia in male Wistar albino rats with streptozotocin-induced diabetes mellitus randomly divided into three groups (each n = 28). Group I received topical 0.09% saline solution, Group II received terramycin, and Group III received mad honey. Wound tissues were collected after decapitation on days 3, 7, 14, or 19 post-wounding. Levels of malondialdehyde (MDA), and activities of the antioxidant enzymes superoxide dismutase, glutathione peroxidase, and catalase were determined using quantitative methods. Gene expressions of the inflammatory markers such as tumor necrosis factor alpha (TNF-α) and metalloproteinase 9 (MMP-9) and of the anti-inflammatory marker interleukin-10 (IL-10) were analyzed using real-time reverse transcription polymerase chain reaction. Wound tissues were also subjected to histopathological examination. Significantly lower MDA levels and TNF-α and MMP-9 expression, and increased antioxidant enzyme activities and IL-10 expression were observed in the mad honey group (Group III) compared with Group I. These parameters exhibited similar changes in Group II compared with Group I. In conclusion, the topical use of mad honey improves the healing of diabetic wounds in examined rats.
Konular
Atıflar
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24 atıf
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Yerel katalogda bu makaleye atıf yapan 12 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
- Comparison of Protective Effect of Aqueous and Ethanolic Extracts of Propolis against Gastric Ulceration in Rats 2023
- Characterization of the black cumin (Nigella sativa L.) honey from Turkiye 2023
- Antioxidant activity and phenolic composition of propolis from Marmara region, Turkey 2023
- Characterization of the black cumin (Nigella sativa L.) honey from Türkiye 2023
- Characterization of the black cumin (Nigella sativa L.) honey from Türkiye 2023
- Sinapic acid-loaded gel accelerates diabetic wound healing process by promoting re-epithelialization and attenuating oxidative stress in rats 2023
- The effects of cream-based Triticum vulgare with and without therapeutic ultrasound on excisional wound healing in diabetic rats 2023
- Determination of Grayanotoxin-III amount in the rhododendron honey and flowers samples using UHPLC-Orbitrap®-HRMS 2025
- Determination of Grayanotoxin-III amount in the rhododendron honey and flowers samples using UHPLC-Orbitrap®-HRMS 2025
- Determination of Grayanotoxin-III amount in the rhododendron honey and flowers samples using UHPLC-Orbitrap®-HRMS 2025