Makale detayı · 2025
Morpholine-modified thiosemicarbazones and thiazolidin-4-ones against Alzheimer’s key enzymes: From synthesis to inhibition
- Yıl
- 2025
- Tür
- article
Veri kaynağı ayrımı
- YÖKSİS YÖKSİS makale kaydı
- YÖKSİS dergi adı Computational Biology and Chemistry
- Katalog eşleşmesi (ISSN) Computational Biology and Chemistry
- OpenAlex OpenAlex zenginleştirmesi (özet, atıf, konular)
Özet
OpenAlex · İngilizce
Exercise-induced oxidative stress results from the overproduction of reactive oxygen and nitrogen species (ROS/RNS) during intense physical activity, potentially impairing muscle function and recovery. Phenolic compounds, abundant in plant-based foods, are known for their potent antioxidant properties and may modulate redox homeostasis in athletes. This review critically examines the dual role of phenolic compounds in exercise physiology, highlighting both their protective antioxidant effects and the risks of excessive intake that may disrupt adaptive responses. We provide an overview of their molecular mechanisms, dose-dependent outcomes, and bioavailability issues, alongside evidence from animal and human studies. Notably, excessive antioxidant supplementation may interfere with beneficial exercise-induced adaptations, including mitochondrial biogenesis. The review also emphasizes the need for personalized antioxidant strategies based on individual training status, exercise intensity, and metabolic variability. Future research should address long-term effects, optimal dosing, and the interaction of phenolic compounds with other dietary antioxidants. Our findings aim to inform evidence-based recommendations for integrating phenolic compounds into exercise recovery and performance strategies.
Konular
Atıflar
OpenAlex cited_by_count. WoS veya Scopus atıf sayısı değildir; o kaynaklar için ayrı kolon yoktur.
63 atıf
OpenAlex cited_by_count (önbellek / veritabanı)
Yerel katalogda bu makaleye atıf yapan 36 yayın (OpenAlex referans eşleşmesi; tam dünya listesi değildir).
- Esculetin attenuates doxorubicin-induced cardiac toxicity: Evidence from gene expression, enzyme activity, and molecular docking analyses 2025
- Esculetin attenuates doxorubicin-induced cardiac toxicity: Evidence from gene expression, enzyme activity, and molecular docking analyses 2026
- Esculetin attenuates doxorubicin-induced cardiac toxicity: Evidence from gene expression, enzyme activity, and molecular docking analyses 2026
- Esculetin attenuates doxorubicin-induced cardiac toxicity: Evidence from gene expression, enzyme activity, and molecular docking analyses 2026
- Esculetin attenuates doxorubicin-induced cardiac toxicity: Evidence from gene expression, enzyme activity, and molecular docking analyses 2025
- Exploring the multipharmacological potential of Rosa pisiformis: an integrated approach combining LC-MS/MS, GC-MS, enzyme inhibition, docking, and pathway enrichment 2025
- Isatis glauca Aucher Ex Boiss. Subsp. Glauca (Indigo) Extracts as Enzyme Inhibitors: A Biochemical Study 2025
- Exploring the multipharmacological potential of Rosa pisiformis: an integrated approach combining LC-MS/MS, GC-MS, enzyme inhibition, docking, and pathway enrichment 2025
- Integrated bioinformatics and molecular docking ıdentify CCNB1, CDK1, and CYP1A2 as therapeutic targets of phytochemicals in hepatocellular carcinoma 2026
- Esculetin Attenuates Doxorubicin‐Induced Cardiotoxicity via Modulation of Apoptotic and Mitochondrial Gene Expression Networks 2025