Serum Chemerin, Vaspin, Oxidative Stress and Inflammation Markers in Subclinical Hypothyroidism/Hyperthyroidism

OpenAlex İngilizce

Purpose: Subclinical thyroid diseases constitute the first stage of clinical thyroid, so it is important to investigate underlying mechanisms. Clinical studies have revealed changes in some adipokines concerning thyroid disorders. Relationship chemerin and vaspin adipokines with thyroid hormones are not clear. So, it was aimed to evaluate chemerin, vaspin, oxidative stress and inflammation markers in subclinical hypothyroidism/hyperthyroidism. Material and Methods: The study included 38 SubHyper, 31 SubHypo and 44 controls. Serum chemerin, vaspin, IL-10, CRP, and Ox-LDL were measured with ELISA, while TAS and TOS were spectrofometric method. Results: Serum chemerin were higher in SubHypo, while lower in SubHyper compared to controls. Vaspin levels of subclinical thyroid patients were lower than controls. IL-10 were lower in SubHyper; CRP were higher in both patient groups than controls. TAS were higher in SubHypo; TOS and OSI were lower in SubHyper patients. Conclusion: Increased total antioxidant and CRP in SubHypo and decreased total oxidants, IL-10 and OSI in SubHyper indicated that oxidant-antioxidant balance is impaired suggesting that subclinical thyroid diseases may cause changes in inflammation and defense mechanism. Decrease in chemerin in SubHyper and vaspin in SubHypo and SubHyper show that chemerin and vaspin may be candidates as biomarkers in subclinical thyroid diseases.