Caveolin-1 and cellular processes

Caveolae in endothelial cells have been implicated as plasma membrane microdomains that sense or transduce hemodynamic changes into biochemical signals that regulate vascular function. Therefore we compared long- and short-term flow-mediated mechanotransduction in vessels from WT mice, caveolin-1 knockout (Cav-1 KO) m…

• FATOŞ İLKAY ALP YILDIRIM

Leukocyte adhesion deficiency-1/variant (LAD1v) syndrome presents early in life and manifests by infections without pus formation in the presence of a leukocytosis combined with a Glanzmann-type bleeding disorder, resulting from a hematopoietic defect in integrin activation. In 7 consanguineous families, we previously…

• ŞULE ÜNAL CANGÜL

BACKGROUND: Mutations in the ganglioside-induced differentiation-associated protein 1 gene (GDAP1) were recently shown to be responsible for autosomal recessive (AR) demyelinating Charcot-Marie-Tooth disease (CMT) type 4A (CMT4A) as well as AR axonal CMT with vocal cord paralysis. METHODS: The coding region of GDAP1 w…

• SEVİM ERDEM ÖZDAMAR

Bernard-Soulier syndrome (BSS) is a rare autosomal recessive bleeding disorder characterized by defects of the GPIb-IX-V complex, a platelet receptor for von Willebrand factor (VWF). Most of the mutations identified in the genes encoding for the GP1BA (GPIbα), GP1BB (GPIbβ), and GP9 (GPIX) subunits prevent expression…

• ÜMRAN ÇALIŞKAN

Bernard-Soulier syndrome (BSS) is a rare autosomal recessive bleeding disorder characterized by defects of the GPIb-IX-V complex, a platelet receptor for von Willebrand factor (VWF). Most of the mutations identified in the genes encoding for the GP1BA (GPIbα), GP1BB (GPIbβ), and GP9 (GPIX) subunits prevent expression…

• HÜSEYİN TOKGÖZ

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• ADNAN YÜKSEL

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• GÖZDE YEŞİL SAYIN
• YASEMİN ALANAY

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• GÖZDE YEŞİL SAYIN
• YASEMİN ALANAY

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• YASEMİN ALANAY

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• YASEMİN ALANAY

To the editor: Integrins constitute the major and largest cell adhesion receptor family. These heterodimers undergo dramatic allosteric conformational changes in response to various activation signals acting on their beta integrin subunit tails.[1][1] In hematopoietic cells, these events are

• SARA ŞEBNEM KILIÇ GÜLTEKİN

Objective Serrated colorectal cancer (CRC) accounts for approximately 25% of cases and includes tumours that are among the most treatment resistant and with worst outcomes. This CRC subtype is associated with activating mutations in the mitogen-activated kinase pathway gene, BRAF, and epigenetic modifications termed t…