Synthesis and Reactivity of Sulfur-Containing Compounds

Leishmaniasis is a neglected tropical disease with significant global health implications. Over 20 species of Leishmania are pathogenic to humans and can be found in the blood and various tissues. Leishmaniasis is one of the seven most significant tropical diseases and is second only to malaria in terms of mortality c…

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Benzotriazole-mediated thiophene-3,4-imido-L-amino acid esters (L-phenylalanine methyl ester, L-tyrosine methyl ester, and L-aspartic acid methyl ester) were synthesised from thiophene-3,4- dicarboxylic acid via thiophene-3,4-anhydride to model the reactions of aromatic, phenolic, and polar amino acids, respectively.…

Thiazole, a five-membered heterocyclic skeleton found in numerous commercially marketed drugs and various natural products, has gained significant attention in the field of medicinal chemistry. Thiazole derivatives have diverse therapeutic potential, including neuroprotective, antidiabetic, antioxidant, antimicrobial,…

This review presents a comprehensive examination of the syntheses, structural modifications, and biological activities of the 2-sulfanilidene-2,3-dihydropyridopyrimidin-4(1H)-one ring systems. The study is divided into four main sections covering compounds possessing the core structures of pyrido[2,3-d]-, pyrido[3,4-d…

Cancer is one of the world’s most deadly diseases. According to the American Cancer Society, 2 million people in the US are diagnosed with cancer, and nearly half of the patients died in 2024. Many challenges need to be overcome when treating cancer, such as the destructive effect of long-term treatment and drug resis…

• AYBÜKE ZÜLEYHA KAYA

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• ARZU BİNİCİ

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• NEŞE TAŞCİ
• SENEM AKKOÇ

Cancer is one of the world’s most deadly diseases. According to the American Cancer Society, 2 million people in the US are diagnosed with cancer, and nearly half of the patients died in 2024. Many challenges need to be overcome when treating cancer, such as the destructive effect of long-term treatment and drug resis…

• ASAF EVRİM EVREN

The present study aimed to design, synthesize, and evaluate a new series of thieno[3,2-d]pyrimidin-4(3H)-one-based Schiff bases as potential antileishmanial agents against Leishmania major (L. major). A series of twenty thieno[3,2-d]pyrimidine Schiff base derivatives were synthesized and characterized using FTIR, NMR,…

• BAYCAN MOR

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• ABDULLAH BİÇER

The present study aimed to design, synthesize, and evaluate a new series of thieno[3,2-d]pyrimidin-4(3H)-one-based Schiff bases as potential antileishmanial agents against Leishmania major (L. major). A series of twenty thieno[3,2-d]pyrimidine Schiff base derivatives were synthesized and characterized using FTIR, NMR,…

• NERİMAN MOR