Diet, Metabolism, and Disease

Aim: High-fructose corn syrup (HFCS) has been associated with metabolic and inflammatory disturbances, including pulmonary inflammatory injury. Due to its known anti-inflammatory and tissue-protective properties, this study aimed to investigate the protective effects of dexpanthenol (DEXP) against HFCS-induced structu…

Özet henüz yok.

Excessive intake of high-fructose corn syrup (HFCS) contributes to pediatric metabolic dysfunction-associated steatotic liver disease, but the mechanisms linking fructose exposure to inflammatory cell death remain incompletely defined. This study investigated whether dexpanthenol (DEX) attenuates HFCS-induced liver in…

Abstract Obezite, insülin sinyal mekanizmalarındaki bozulmalar neticesinde glukoz homeostazının kaybına ve sistemik metabolik disfonksiyona yol açan küresel bir sağlık sorunudur. Bu sistematik derlemenin amacı, obezite modellerinde uygulanan farklı kronik egzersiz müdahalelerinin; temel glukoz metabolizması belirteçle…

Abstract Background Cannabidiol (CBD) has attracted attention as a potential anticancer agent due to its observed efficacy, particularly in breast cancer. However, the exact molecular pathway through which it exerts its anticancer effects remains unknown. The present study aimed to investigate the effects of CBD on th…

This study aimed to evaluate two intermittent fasting (IF) protocols (8:16 and 5:2) on sperm parameters and testicular microarchitecture in rats fed a high-fructose (HF) diet. Forty 12-week-old male Wistar albino rats were divided into four groups: Control, HF(20% fructose), (8:16)+HF (16-h daily fast), and (5:2)+HF(t…

Özet henüz yok.

Özet henüz yok.

Endometrial cancer is a common gynecologic malignancy for which therapeutic options remain limited in advanced or treatment-resistant disease.Natural compounds that selectively perturb cancer-associated redox signaling and survival pathways may offer novel anticancer strategies.The present study investigated the antic…

BDNF and its receptor, TrkB, are essential regulators of energy homeostasis in both central and peripheral tissues, including the liver. This study aimed to investigate the effects of ANA-12, a selective TrkB antagonist, on hepatic mitochondrial enzyme activities and biochemical parameters in a mouse model of sucrose-…

Özet henüz yok.

This study investigated the effects of an Origanum onites L. extract, carvacrol, and metformin on the metabolic syndrome (MetS) induced by a high-fat, high-fructose diet (HFFD) in rats.Oregano was extracted using supercritical CO₂, and profiles of phenolics and volatile organic compounds were analyzed via high-perform…