Nephrotoxicity and Medicinal Plants

INTRODUCTION: Pauci-immune necrotizing and crescentic glomerulonephritis (PiNCGN) is a leading cause of rapidly progressive kidney failure. Several prognostic tools - Berden classification, Mayo Clinic Chronicity Score (MCCS), Percentage of ANCA Crescents Score (PACS), ANCA Renal Risk Score (ARRS), and the improved AN…

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Methotrexate (MTX) is widely used in the treatment of malignancies and inflammatory disorders, but nephrotoxicity remains a major adverse effect. Naringenin (NAR), a natural flavonoid, has antioxidant, anti-inflammatory, and nephroprotective properties. This study investigated the potential protective effects of NAR a…

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Amoxicillin, one of the most frequently prescribed β-lactam antibiotics in both human and veterinary medicine, is released into the environment due to its widespread use; it enters aquatic ecosystems and especially the food chain, posing potential risks to non-target organisms. This study aimed to investigate the geno…

Background: Rhabdomyolysis is a potentially life-threatening condition that may lead to acute kidney injury (AKI). Although nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used, diclofenac-associated rhabdomyolysis is exceedingly rare. Herbal products, often perceived as harmless, may also contribute to nephr…

Objective: The aim of this study was to provide information on the demographic characteristics and laboratory parameters of primary glomerulonephritis (PGN) patients diagnosed at our center and to determine the epidemiology of PGN in our region.Method: 148 adult PGN cases diagnosed via percutaneous renal biopsy at our…

Immune checkpoint inhibitors (ICPIs) have transformed cancer treatment but may cause immune-related adverse events (irAEs) affecting multiple organ systems. Renal irAEs, particularly tubulointerstitial nephritis (TIN), are uncommon yet clinically significant, and their optimal diagnosis and management — including the…

ABSTRACT Brucellosis is the most frequently encountered zoonotic disease in regions like Turkey. Osteoarticular involvement is the most common complication, and standard treatment involves doxycycline and rifampicin. Rifampicin is generally well tolerated; however, hepatotoxicity is a known side effect, and acute kidn…

This study investigates the antioxidant activity, the phytochemical compounds, the total phenolic and flavonoid contents, anticancer potential, and photodynamic therapy (PDT) effectiveness of Aristolochia samsunensis methanol extract. The IC50 value of the methanol extract from A. samsunensis was measured as 189.64 ±…

This study investigates the antioxidant activity, the phytochemical compounds, the total phenolic and flavonoid contents, anticancer potential, and photodynamic therapy (PDT) effectiveness of Aristolochia samsunensis methanol extract. The IC50 value of the methanol extract from A. samsunensis was measured as 189.64 ±…

This study investigates the antioxidant activity, the phytochemical compounds, the total phenolic and flavonoid contents, anticancer potential, and photodynamic therapy (PDT) effectiveness of Aristolochia samsunensis methanol extract. The IC50 value of the methanol extract from A. samsunensis was measured as 189.64 ±…