Advanced Biosensing Techniques and Applications

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The interaction of nanoparticles within the micromixer-assisted microfluidic platforms offers a powerful strategy for controlled biomarker capture by simultaneously enhancing surface-activated binding and transport-limited interactions under laminar flow conditions. In this study, poly(acrylic acid)-coated superparama…

Overexpression of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) is common in solid tumors like breast, colorectal, and head and neck cancers, driving oncogenic signaling, therapy resistance, and poor prognosis. Monotherapies often fall short in fully suppressing tumor prog…

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Abstract Multicenter studies are essential for benchmarking analytical workflows, yet their interpretation is often confounded by the combined effects of experimental protocols and instrumentation. To address this challenge, we introduce a simple normalization-based analytical framework, the recovery metric ( ρ ), des…

Functional assay platforms offer a powerful approach for assessing drug treatments by directly probing cellular responses. However, their clinical translation is limited due to long assay times, bulk measurements, and low throughput. In this study, we present a high-throughput plasmonic functional assay platform to de…

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Meningitis and encephalitis necessitate rapid pathogen identification to guide therapy, as conventional methods are time-consuming. This study evaluated both the wet-lab analytical performance and the clinical performance evaluation of the Bioeksen Meningitis/Encephalitis Panel (BS-MEP) integrated onto the fully autom…

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We present a dual-wavelength, multi-parametric Interferometric Reflectance Imaging Sensor (MP-IRIS) for real-time, label free, multiplexed binding kinetic measurements without the "bulk-effect". Our platform dynamically tracks the conditions of the solution and corrects in real time, demonstrating a reduction in bulk…

The immuno-infrared sensor (iRS) detects misfolding of biomarker proteins in blood and provides thereby a very early and easily accessible diagnosis of Alzheimer's and Parkinson's disease. Only in early stages recently approved therapeutic Alzheimer's drugs work efficiently. In symptom-free stages, lifestyle change ca…

In this study, we used flexible and inexpensive diatomite/AgNPs strips and Layer-by-Layer (LbL) assembly to develop sandwich assays for the detection of cancer biomarkers of interest via Surface-enhanced Raman scattering (SERS). The modified SERS active strips were used to capture antigens of interest, incubate Raman…