Aldose Reductase and Taurine

extract demonstrated contrasting regulatory profiles, which exhibited a broader modulation of endoplasmic reticulum stress and mitogen-activated protein kinase signaling. Collectively, the findings demonstrate that ESF selectively attenuates inflammatory and angiogenic responses by specifically inhibiting the NF-κB-VE…

Abstract Objectives Cholestasis, characterized by impaired bile flow and bile accumulation, leads to progressive liver injury largely mediated by oxidative stress. Taurine, a conditionally essential amino acid with antioxidant and cytoprotective properties, may protect against cholestatic liver damage. This study inve…

A common food additive, monosodium glutamate (MSG), is a source of glutamate, the primary excitatory neurotransmitter in the central nervous system, and has been associated with neuronal damage at high levels. Taurine (TAU), a naturally occurring amino acid, is widely used in energy drinks alongside caffeine and sugar…

antidiabetic assessment in streptozotocin-induced diabetic rats. Treatment with the selected derivatives improved glycemic control and favorably modulated diabetes-associated physiological and biochemical alterations, including body weight changes, lipid profile disturbances, and elevated hepatic biomarkers. Molecular…

Sodium–glucose cotransporter-2 (SGLT-2) inhibitors show promising hepatic benefits in patients with metabolic dysfunction–associated steatotic liver disease (MASLD); however, their effects on underlying metabolic mechanisms remain unclear. This study included 29 patients with type 2 diabetes mellitus (T2DM) and MASLD…

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Heat stress disrupts cellular homeostasis in cells by inducing protein misfolding, activating endoplasmic reticulum stress pathways and impairing cell survival mechanisms. The present study aimed to evaluate the cytoprotective effects of tauroursodeoxycholic acid (TUDCA) against heat stress-induced cellular damage in…

BACKGROUND: To analyze the potential role of serum and urinary mindin as biomarkers for diabetic retinopathy (DR) severity in patients with type 2 diabetes mellitus (DM). METHODS: This prospective, cross-sectional study included 101 participants allocated into four groups: DM without DR (n = 26), DM with non-prolifera…

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Abstract Diabetes mellitus is a multifactorial metabolic disorder in which sustained post-prandial hyperglycaemia and aberrant activation of the polyol pathway contribute to disease progression and long-term complications. Simultaneous modulation of digestive enzymes and aldose reductase (ALR2) therefore represents a…

Aim: Maternal taurine supplementation has been shown to exert protective effects following a maternal cafeteria diet on offspring growth and metabolism. However, the long-term effects of maternal cafeteria diet on offspring’s metabolism and energy substrates remain unclear. This study aimed to examine the effects of m…

Although the impact of COVID-19, caused by SARS-CoV-2, may appear to have diminished in recent years, the emergence of new variants still continues to cause significant global health and economic challenges. While numerous metabolomic studies have explored serum-based alterations linked to the infection, investigation…