Heparin-Induced Thrombocytopenia and Thrombosis

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• MACİT KALÇIK

Aim: Immune thrombocytopenia (ITP) is an autoimmune disorder with incompletely understood immunopathogenesis. This study aimed to evaluate the serum levels of monocyte-derived chemokines—CCL1, CCL3, CCL4, and CCL16—in newly diagnosed ITP patients, with a focus on their potential diagnostic and pathogenic relevance.Mat…

Objective: To evaluate the association between second-dose vaccination status, clinical characteristics, treatment modalities, and laboratory parameters with intensive care unit (ICU) mortality among patients with COVID-19 who had received at least one dose of vaccination.Methods: This single-center retrospective coho…

OBJECTIVE: The clinical relevance of inherited thrombophilia-related polymorphisms in COVID-19 remains uncertain. This study investigated the distribution of Factor V Leiden (FVL) G1691A and MTHFR A1298C polymorphisms in patients with COVID-19 and associations with laboratory findings and short-term mortality. METHODS…

Background: Intermediate-high-risk acute pulmonary embolism (APE) presents a clinical challenge, as patients are hemodynamically stable at admission yet carry a substantial risk of deterioration requiring rescue thrombolytic therapy. This study evaluated whether admission complete blood count-derived inflammatory indi…

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by increased platelet destruction and impaired platelet production. The role of T-cell subsets and platelet surface markers in ITP pathogenesis remains incompletely understood. To evaluate T-cell subpopulations and platelet surface marker expression…

Aim This study aimed to investigate whether a biomarker can indicate pulmonary thromboembolism (PTE), which plays a major role in the severity and mortality of COVID-19, at the start of treatment. Materials and Methods A total of 160 adult patients who were admitted to the Chest Diseases Clinic between April 2020 and…

Objectives Evidence-based data on the management of thrombocytopenia in systemic lupus erythematosus (SLE) and the platelet threshold for initiating therapy remain limited. This study aimed to evaluate treatment responses in patients with severe immune thrombocytopenia associated with SLE (SLE-ITP) and to assess the i…

Introduction: The aim of this study was to investigate whether the doses of heparin and protamine used for anticoagulation and neutralization during cardiopulmonary bypass (CPB) vary according to ABO blood groups and demographic characteristics. Methods: A total of 839 patients who underwent cardiac surgery between 20…

BACKGROUND: Cancer and atrial fibrillation frequently coexist. Intensive care adds hemodynamic stress, organ failure, and competing bleeding risk. Whether platelet-defined thrombocytopenia modifies the association between an ICU-onset atrial fibrillation surrogate and short-term outcomes in patients with cancer remain…

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