Autoimmune and Inflammatory Disorders

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Abstract Background Crohn’s disease (CD)-related complex perianal fistula (cPAF) is difficult to treat, and iv-anti–tumor necrosis factor (TNF) remains the standard medical option. Recent switch studies suggest that sc-Infliximab (IFX) is not inferior to iv-IFX for luminal CD. In this study, we compared iv-IFX and sc-…

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Cite this article as: Günegül Y, Tozlu M, Demiral YE, Eminler AT, Uslan Mİ. Leukocytoclastic vasculitis occurring during upadacitinib therapy in ulcerative colitis: A case report. Turk J Gastroenterol. Published online January 28, 2026. doi: 10.5152/tjg.2026.25681.

Background: To determine intestinal penetrating complications in patients with Crohn's disease (CD) and to retrospectively evaluate clinical characteristics, the frequency of accompanying stenosing and perianal complications, management strategies, and predictors of the need for surgical intervention. Materials and Me…

Abstract Background Optimal sequencing of therapy in Crohn’s disease after anti-TNF failure remains uncertain. We compared the real-world effectiveness and safety of vedolizumab and ustekinumab in this setting. Methods This retrospective multicenter cohort included 482 patients with moderate-to-severe Crohn’s disease…

Objectives: The significance of granulomas has still not been clarified in pediatric onset Crohn’s disease (CD). The aim of this study was to investigate the phenotype and clinical course in CD patients with granuloma in a comprehensive cohort. Materials and Methods: Histopathological findings of 317 endoscopic proced…

Objectives: The objective of this study was to evaluate and update the evidence on pharmacologic and interventional treatments for major organ involvement in Behçet syndrome (BS), in order to inform the 2025 update of the European Alliance of Associations for Rheumatology recommendations. Methods: A systematic literat…

To determine the diagnostic value of imaging; to assess the relationship between clinical and laboratory features and disease progression; and to evaluate how these parameters influence prognosis in Neuro-Behçet’s syndrome (NBS).

We report the case of a 30-year-old female patient with Crohn's disease who was receiving infliximab and mesalazine therapy. She presented with left ear pain accompanied by bloody diarrhea and abdominal pain. Initial treatment with ciprofloxacin and aluminum acetate was ineffective, requiring hospitalization. She was…

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