Cholinesterase and Neurodegenerative Diseases

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• ŞEYMA ATEŞOĞLU

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High Resolution Image Download MS PowerPoint Slide A new series of squamolone-based γ-lactam derivatives ( SQ1a–SQ1l ) was rationally designed, synthesized, and structurally confirmed via FT-IR, NMR, and HRMS analyses. The synthesized compounds were evaluated for their inhibitory potential against human carbonic anhyd…

Etoxazole is a widely used oxazoline acaricide in agriculture; however, its toxicological profile in mammalian systems remains insufficiently characterized. This study investigated the dose-dependent effects of subchronic etoxazole exposure on serum biochemical, genotoxic, and haematological parameters in female Wista…

Coniferyl alcohol and coniferyl aldehyde are precursors of lignin and are used in spices and the pharmaceutical industry. In this work, antioxidant, anticholinergic, antidiabetic, and antiglaucoma effects of coniferyl alcohol and aldehyde were evaluated and compared against the standards. To determine the antioxidant…

Alzheimer Hastalığı (AH), patolojik olarak nöronal kayıp, amiloid-beta (Aβ) plaklarının ve hiperfosforile tau nörofibriler yumaklarının (NFY'ler) birikimiyle karakterize, ilerleyici bir nörodejeneratif bozukluktur. Mevcut farmakolojik yönetim, bilişsel işlevi artıran veya eksitotoksisiteyi azaltan asetilkolinesteraz i…

Acetylcholinesterase is one of the key enzymes responsible for the hydrolysis of acetylcholine at cholinergic synapses. Inhibition of AChE activity may contribute to an increase in acetylcholine levels in the synaptic cleft and to the enhancement of cholinergic neurotransmission. Therefore, AChE inhibitors are conside…

Acetylcholinesterase is one of the key enzymes responsible for the hydrolysis of acetylcholine at cholinergic synapses. Inhibition of AChE activity may contribute to an increase in acetylcholine levels in the synaptic cleft and to the enhancement of cholinergic neurotransmission. Therefore, AChE inhibitors are conside…

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In this study, four novel pyrimidine-sulfonate hybrid molecules (6a-d) were synthesized and characterized using spectroscopic techniques. The interactions affinity values of 6a-6d with enzymes acetylcholinesterase, glutathione s-transferase, pancreatic lipase and tyrosinase were calculated by means of molecular dockin…

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