Hormonal Regulation and Hypertension

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Aim: The suprarenal (adrenal) glands are supplied by a rich arterial network that typically arises from the inferior phrenic arteries (superior suprarenal), the abdominal aorta (middle suprarenal), and the renal arteries (inferior suprarenal). However, the frequency, diversity, and laterality of arterial variants vary…

Thyroid hormones (THs) are critical regulators of human development, cellular differentiation, and metabolism. While their systemic effects are well established, their role in adrenal androgen production remains poorly defined. Moreover, potential feedback regulation of the hypothalamic-pituitary-thyroid (HPT) axis by…

INTRODUCTION: Obesity is a chronic, multifactorial condition which is a global health challenge. In general, obesity is defined by excessive fat accumulation and associated with the risk of numerous conditions, including type 2 diabetes mellitus (T2DM), cardiovascular disease, heart failure, and metabolic dysfunction-…

INTRODUCTION: The accurate differentiation of fat-poor and atypical adrenal adenomas from metastases remains a diagnostic challenge. This study aimed to evaluate the predictive value of MRI-based radiomic, radiologic, and combined radiomic-radiologic machine learning (ML) models. METHODS: This single-center retrospect…

Background/Objectives: To compare computed tomography (CT)-derived body composition parameters across hormonal subtypes of adrenal adenomas and investigate their associations with hormonal activity. Methods: This retrospective study included 171 patients with unilateral adrenal adenomas categorized as Cushing syndrome…

Objective: The aims of this study were to determine the prevalence of anxiety disorder in patients with primary hyperaldosteronism (PA), to compare it with patients diagnosed with essential hypertension (EHT) after exclusion of secondary causes, and to evaluate the association between treatment modalities for PA and c…

ÖZAmaç21-hidroksilaz eksikliği (21OHE) çocuklarda primer adrenal yetmezliğin en sık nedenidir.Özellikle su ve tuz kaybına bağlı mortalite ve morbiditeyi önlemek amacı ile hastalığın yenidoğan tarama programlarına dâhil edilmesi önerilir. Türkiye’de 2017 yılında dört ilde pilot tarama başlatılmış, 2022 yılında ise tüm…

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BACKGROUND/AIM: Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor, with limited survival despite standard treatments such as surgery, radiotherapy, and chemotherapy. High recurrence rates after gross total resection underline the need for identifying new therapeutic targets. Angiotensin-converti…

Abstract Introduction Primary bilateral macronodular adrenal hyperplasia (PBMAH) is an uncommon cause of endogenous Cushing’s syndrome (CS). Pheochromocytoma (PCC) is another adrenal tumor derived from the neural crest and arising in the adrenal medulla. Here, we report a case of recurrent overt CS due to PBMAH, occur…

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