Circular RNAs in diseases

Background: Non-small cell lung cancer (NSCLC) accounts for the majority of lung cancer cases. Circulating microRNAs (miRNAs) have emerged as promising non-invasive biomarkers for cancer detection. In this exploratory study, we investigated the diagnostic and prognostic value of four circulating miRNAs (miR-107, miR-1…

MicroRNAs (miRNAs) are evolutionarily conserved, non-coding RNA molecules approximately 18–25 nucleotides in length that regulate gene expression at the post-transcriptional level. Their principal mechanism of action is post-transcriptional gene silencing via RNA interference, achieved by binding to complementary sequ…

Aim: MicroRNAs are small endogenous RNA molecules that do not code for proteins but have the capacity to influence cancer development by promoting or inhibiting it. They play normal biological roles in regulating cell metabolism, development, apoptosis, and metastasis. While numerous studies on the functional mechanis…

Examples of lesions in DEN-treated WT and miR-146a−/− female mouse livers. A and B, Focus of cytologic alteration (FCA). At 10× (A), the lesion appears as a small (less than 2 mm) zone of more darkly staining hepatocytes. At 40×, nonlesional hepatocytes at the periphery of the lesion (top) appear larger than cells wit…

Özet henüz yok.

Background/Objective: MicroRNA-21 (miR-21) is one of the most widely studied oncogenic microRNAs and has been implicated in breast cancer progression, therapy resistance, and metastatic potential. However, its utility as a long-term prognostic biomarker in patients undergoing mastectomy remains insufficiently clarifie…

Background/aim: Breast cancer represents the foremost cause of cancer-related mortality among women worldwide and is characterized by a markedly high metastatic potential, contributing substantially to its clinical severity and poor prognosis. This study aimed to evaluate the interrelationship among silent information…

Background: Lung cancer is one of the world's leading causes of cancer-related death. A tumor biopsy is the gold standard for diagnosis but may not be representative of the whole tumor. We therefore need non-invasive biomarkers to guide us in structure, mass, prognosis and treatment. Therefore, alternative non-invasiv…

Objective: Leukemia stem cells (LSCs) are central to therapy resistance and disease relapse. Long non-coding RNAs (lncRNAs) act as key epigenetic regulators whose dysregulation sustains leukemic stemness. This study aimed to evaluate whether resveratrol, a natural polyphenol, can selectively modulate the lncRNA expres…

Background: Endometrial cancer (EC) is the second most common gynecological malignancy and remains a major contributor to morbidity and mortality among women worldwide. Current diagnostic and prognostic tools have limited accuracy, highlighting the need for reliable, non-invasive biomarkers. Non-coding RNAs (ncRNAs),…

Breast cancer continues to be a significant worldwide issue. Systemic chemotherapy remains the mainstay of breast cancer therapy despite advancements in technology. However, their side effects and the decreased patient quality of life hinder long-term therapeutic success. Personalized treatment is more crucial for bre…

Özet henüz yok.