Birth, Development, and Health

To investigate the relationship between maternal inflammatory indices and neonatal interleukin-6 (IL-6) response in preterm infants and to evaluate its association with prolonged hospitalization and specific neonatal morbidities. This retrospective single-center study included 50 preterm neonates hospitalized between…

Background: Zonulin, a biomarker linked to intestinal barrier dysfunction, may contribute to fetal growth disorders such as intrauterine growth restriction (IUGR) and small-for-gestational-age (SGA) pregnancies. This study evaluated maternal serum zonulin levels as a diagnostic tool for distinguishing IUGR from SGA an…

BACKGROUND: Children with a solitary functioning kidney (SFK) are at risk for hypertension and kidney injury despite compensatory renal growth. However, the relationship between compensatory enlargement and blood pressure abnormalities remains controversial. This study is an exploratory observational study aimed at as…

The Developmental Origins of Health and Disease theory proposes that environmental influences during early life have long-term effects on health outcomes. Although maternal factors have been extensively studied, the impact of paternal obesity on fetal development and pregnancy outcomes has received limited attention.…

Introduction: Studies have demonstrated that insults during development increase the risk for developing diseases later in life, including hypertension, ischemic heart disease, stroke, respiratory disease, diabetes, cancer, as well as psychiatric disorders. Hence, as mitochondrial dysfunction-induced oxidative stress…

Abstract Objective: The objective of this study is to determine whether IMA (Ischemic Modified Albumin), a new oxidative stress marker, can be used to predict the degree of oligozoospermia in infertile men. Materials and Methods: Oligozoospermic male patients (n=113) who remained infertile despite regular, unprotected…

The perinatal period is increasingly recognized as an important determinant of biological aging trajectories and disease susceptibility across the lifespan. This narrative review synthesizes current evidence linking intrauterine exposures to adult health outcomes across three biological dimensions: fetal programming,…

Background: Preterm birth is increasingly recognized as an early-life exposure with potential cardiovascular consequences across the lifespan. Although improved neonatal care has increased survival among individuals born very and extremely preterm, birth history remains rarely incorporated into cardiovascular risk ass…

BACKGROUND/AIMS:The present study investigated whether the triglyceride-glucose (TyG) index could serve as a predictive marker for gestational diabetes mellitus (GDM). MATERIALS AND METHODS:This retrospective case-control analysis included pregnant women who were followed and delivered at our institution between April…

Değişkenler arasındaki ilişkiyi matematiksel olarak modelleyen regresyon yöntemleri, gelişen bilim dünyasında istatistiki yöntemlerden biri olarak modernleşmektedir. Bu doğrultuda makine öğrenmesi yöntemleri klasik yöntemlerden ayrılarak daha uygulanabilir analizler sağlayarak karşımıza çıkmaktadırlar. Bu çalışmada 15…

BACKGROUND: Disrupted feeding timing may alter microbiota profiles and contribute to metabolic disturbances. This study aimed to investigate the impact of maternal chrononutrition during pregnancy on maternal gut and placental microbiota. METHODS: This study was conducted between April 2022 and February 2023 at Erciye…

Objectives: Neonatal hypertension is uncommon but clinically significant due to its systemic complications. Data on the clinical course, etiologies, and outcomes of neonates receiving antihypertensive therapy in the neonatal intensive care unit are limited. This study aimed to describe the clinical characteristics, un…